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Abstract：
The aims of this study were to determine the prevalence and predictors of nocturnal polyuria (NP) in Japanese patients. This multicentral, observational study enrolled patients with the chief complaint of nocturia at 17 Japanese institutions between January 2018 and December 2022. The frequency of daily voiding and volume of urination were evaluated using bladder diaries. NP was diagnosed in patients with an NP index of > 33%. The primary endpoint was NP prevalence in patients with nocturia. The secondary endpoints were the prevalence of NP according to sex and age and the identification of factors predicting NP. This study analyzed 875 eligible patients. NP was present in 590 (67.4%) patients, with prevalence rates of 66.6% and 70.0% in men and women, respectively. Age ≥ 78 years, body mass index (BMI) < 23.0 kg/m2, and patients with ischemic heart or cerebrovascular disease were significant predictors of NP (P < 0.001, P < 0.001, P = 0.014, P = 0.016, respectively). This is the first large multicenter study to investigate the prevalence of NP in Japanese patients with nocturia. NP has a prevalence of 67.4%. Significant predictors of NP include age, BMI, and cardiovascular disease.
摘要：
这项研究的目的是确定日本患者夜间多尿（NP）的患病率和预测因素。这个多中心，观察性研究纳入了2018年1月至2022年12月期间在日本17家机构的主要主诉为夜尿症的患者.使用膀胱日记评估每日排尿的频率和排尿量。NP指数>33%的患者被诊断为NP。主要终点是夜尿症患者的NP患病率。次要终点是根据性别和年龄确定的NP患病率以及预测NP的因素。这项研究分析了875名符合条件的患者。NP存在于590例（67.4%）患者中，男女患病率分别为66.6%和70.0%，分别。年龄≥78岁，体重指数(BMI)<23.0kg/m2,缺血性心脑血管疾病患者是NP的显著预测因子(分别为P<0.001,P<0.001,P=0.014,P=0.016)。这是第一个调查日本夜尿症患者NP患病率的大型多中心研究。NP的患病率为67.4%。NP的重要预测因素包括年龄，BMI,和心血管疾病。
