Abstract：
Given the rising frequency of drug shortages in hospitals, interdisciplinary collaboration is necessary to manage medications, modify electronic medical records, and evaluate safety outcomes. One such shortage impacted lorazepam injection, a medication commonly used in palliative care to treat anxiety, agitation, and seizures. In anticipation of the lorazepam shortage in the summer of 2022, pharmacy staff collaborated with palliative care physicians to identify alternative treatment recommendations when providers were prohibited from ordering lorazepam injection. Before the shortage, lorazepam was used an average of 95 times per month on the palliative care unit. The overall use of benzodiazepines decreased substantially following the recommendation for the therapeutic alternative, midazolam, during the shortage. Once the shortage ended, use roughly returned to pre-shortage baselines. During this time, there were no patient safety events documented on the palliative care unit. Moreover, no changes to the care experience were reported by patients, family/caregivers, providers, or staff. The collaborative effort between pharmacy and palliative care specialists resulted in alternative treatments for palliative care patients during the drug shortage. This preserved the hospital\'s supply of lorazepam injection for a patient population with no suitable alternatives while still allowing for management of palliative patients.
摘要：
鉴于医院药品短缺的频率越来越高，跨学科合作对于管理药物是必要的，修改电子病历,并评估安全性结果。一个这样的短缺影响了劳拉西泮注射液，一种常用于姑息治疗的药物，激动,和癫痫发作。由于预期2022年夏季劳拉西泮短缺，药房工作人员与姑息治疗医生合作，以确定禁止提供者订购劳拉西泮注射的替代治疗建议。在短缺之前，在姑息治疗病房平均每月使用劳拉西泮95次。在推荐治疗替代方案后，苯二氮卓类药物的总体使用量大幅下降，咪达唑仑,在短缺期间。一旦短缺结束，使用大致恢复到短缺前的基线。在此期间,姑息治疗病房没有记录患者安全事件.此外，患者没有报告护理体验的变化，家庭/看护人,提供者,或工作人员。药房和姑息治疗专家之间的合作努力导致了药物短缺期间姑息治疗患者的替代疗法。这保留了医院对没有合适替代品的患者人群的劳拉西泮注射液的供应，同时仍允许姑息患者的管理。
