PDF(Pubmed)
Abstract：
UNASSIGNED: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been shown to be detectable in blood from infected individuals. Though RNAemia frequencies are typically low, the presence of potentially infectious virus potentially poses a transmission risk during blood transfusion.
UNASSIGNED: Archived plasma samples were collected from blood donors who later reported possible SARS-CoV-2 infection with the wild-type strain, Delta variant, or Omicron variant. This was based on either symptom onset or a positive test within 2 weeks from their donation. Donations were tested for SARS-CoV-2 RNA, and information on symptoms and testing results were gathered during postdonation interview.
UNASSIGNED: Of 518 archived plasma samples tested, 19 (3.7%) were found to have detectable levels of SARS-CoV-2 RNA. SARS-CoV-2 RNA was detected in donors who donated during the Delta (10/141 [7.1%]) and Omicron (9/162 [5.6%]) waves. SARS-CoV-2 RNA was not detected in donors who donated during the wild-type wave (0/215). Seventeen of 19 RNAemic donors reported symptom onset or a positive test within 2 days of donating. SARS-CoV-2 RNA was detected in asymptomatic or presymptomatic blood donors.
UNASSIGNED: Despite RNAemia being correlated with SARS-CoV-2 disease severity, RNAemia was detected in asymptomatic or presymptomatic blood donors.
UNASSIGNED: Archived plasma samples were collected from blood donors who later reported possible SARS-CoV-2 infection with the wild-type strain, Delta variant, or Omicron variant. This was based on either symptom onset or a positive test within 2 weeks from their donation. Donations were tested for SARS-CoV-2 RNA, and information on symptoms and testing results were gathered during postdonation interview.
UNASSIGNED: Of 518 archived plasma samples tested, 19 (3.7%) were found to have detectable levels of SARS-CoV-2 RNA. SARS-CoV-2 RNA was detected in donors who donated during the Delta (10/141 [7.1%]) and Omicron (9/162 [5.6%]) waves. SARS-CoV-2 RNA was not detected in donors who donated during the wild-type wave (0/215). Seventeen of 19 RNAemic donors reported symptom onset or a positive test within 2 days of donating. SARS-CoV-2 RNA was detected in asymptomatic or presymptomatic blood donors.
UNASSIGNED: Despite RNAemia being correlated with SARS-CoV-2 disease severity, RNAemia was detected in asymptomatic or presymptomatic blood donors.
摘要：
■严重急性呼吸道综合症冠状病毒2（SARS-CoV-2）感染已被证明可在受感染个体的血液中检测到。尽管RNA血症的频率通常很低，潜在感染性病毒的存在可能会在输血过程中造成传播风险。
■从献血者收集存档的血浆样本，这些献血者后来报告可能感染了野生型菌株的SARS-CoV-2，Delta变体,或Omicron变体。这是基于他们捐赠后2周内的症状发作或阳性测试。测试了捐赠的SARS-CoV-2RNA，在捐赠后访谈期间收集了有关症状和检测结果的信息。
■在测试的518个存档血浆样品中，发现19(3.7%)具有可检测水平的SARS-CoV-2RNA。在Delta（10/141[7.1％]）和Omicron（9/162[5.6％]）波期间捐赠的供体中检测到SARS-CoV-2RNA。在野生型波期间捐赠的供体中未检测到SARS-CoV-2RNA(0/215)。19个RNAemic捐赠者中有17个在捐赠后2天内报告了症状发作或阳性测试。在无症状或有症状的献血者中检测到SARS-CoV-2RNA。
■尽管RNA血症与SARS-CoV-2疾病严重程度相关，在无症状或症状前献血者中检测到RNA血症。
■从献血者收集存档的血浆样本，这些献血者后来报告可能感染了野生型菌株的SARS-CoV-2，Delta变体,或Omicron变体。这是基于他们捐赠后2周内的症状发作或阳性测试。测试了捐赠的SARS-CoV-2RNA，在捐赠后访谈期间收集了有关症状和检测结果的信息。
■在测试的518个存档血浆样品中，发现19(3.7%)具有可检测水平的SARS-CoV-2RNA。在Delta（10/141[7.1％]）和Omicron（9/162[5.6％]）波期间捐赠的供体中检测到SARS-CoV-2RNA。在野生型波期间捐赠的供体中未检测到SARS-CoV-2RNA(0/215)。19个RNAemic捐赠者中有17个在捐赠后2天内报告了症状发作或阳性测试。在无症状或有症状的献血者中检测到SARS-CoV-2RNA。
■尽管RNA血症与SARS-CoV-2疾病严重程度相关，在无症状或症状前献血者中检测到RNA血症。
