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Abstract：
Plasmablastic lymphoma (PBL) is a rare clinicopathological entity that still raises many diagnostic and management difficulties, particularly due to the overlap between plasmablastic lymphomas and myeloma features. We report a clinical presentation of PBL affecting bone marrow in a 43-year-old patient who was admitted for B symptoms, hepatosplenomegaly, and bicytopenia investigation. Based on these findings, acute leukemia was suspected. Bone marrow morphology immunohistochemistry and flow cytometry contributed to establishing the diagnosis of medullary PBL. The patient deteriorated and died due to septic shock. This pathology requires collaboration between clinicians, pathologists, and biologists to confirm the diagnosis early. Nevertheless, a delayed diagnosis may contribute to worsening the prognosis particularly due to advanced stage consultation. Our reported case illustrates a rare clinical presentation affecting bone marrow. In our context, a confrontation between flow cytometry and immunohistochemistry was of interest as it helped to detect the immunological features of this neoplasm.
摘要：
浆细胞淋巴瘤（PBL）是一种罕见的临床病理实体，仍然引起许多诊断和管理困难，特别是由于浆细胞淋巴瘤和骨髓瘤特征之间的重叠。我们报道了一名因B症状入院的43岁患者的PBL影响骨髓的临床表现，肝脾肿大,和双红细胞减少症调查。基于这些发现,怀疑是急性白血病。骨髓形态学免疫组化和流式细胞术有助于建立髓样PBL的诊断。患者病情恶化并因感染性休克死亡。这种病理需要临床医生之间的合作，病理学家,和生物学家早期确认诊断。然而，延迟诊断可能会导致预后恶化，特别是由于晚期会诊。我们报告的病例说明了一种罕见的影响骨髓的临床表现。在我们的背景下，流式细胞术和免疫组织化学之间的对抗引起了人们的兴趣，因为它有助于检测这种肿瘤的免疫学特征。
