PDF(Pubmed)
Abstract：
Introduction The follow-up of patients with autoimmune bullous diseases (AIBDs) was temporarily interrupted during the initial phase of the COVID-19 pandemic due to restrictions in healthcare services, given the high contagiousness and rapid spread of SARS-CoV-2. Our objective was to assess the impact of the initial phase of the COVID-19 pandemic on the treatments and disease activity of AIBD patients. Methods We conducted a telephone survey of patients with AIBDs who had been regularly followed up in our hospital prior to the onset of the pandemic. A structured questionnaire that we designed was used. This questionnaire comprised questions examining the following issues between March and June of 2020: patients\' follow-up, treatment, COVID-19 infection status, and changes in disease activity. Results Thirty-nine patients were included in the study. Among those, 26 (66.7%) were immunosuppressed. The frequency of follow-up for 37 patients (94.9%) changed significantly (p<0.001): 28 patients (71.8%) did not visit the hospital, and 26 of them (92.9%) did not communicate at all. The treatment for 10 patients (25.6%) was altered, either by their physician or by themselves. Disease activity reactivated in patients who altered their own treatments. There was only one patient (2.6%) who contracted COVID-19. Conclusions Documenting this period revealed that some patients were negatively impacted by the pandemic initially. The most significant contributing factor was the interruption of patient-physician communication.
摘要：
简介由于医疗保健服务的限制，在COVID-19大流行的初始阶段，自身免疫性大疱性疾病（AIBDs）患者的随访暂时中断，鉴于SARS-CoV-2的高传染性和快速传播。我们的目标是评估COVID-19大流行的初始阶段对AIBD患者的治疗和疾病活动的影响。方法我们对在大流行发作前在我院定期随访的AIBDs患者进行了电话调查。使用了我们设计的结构化问卷。这份问卷包括在2020年3月至6月期间检查以下问题的问题：患者随访，治疗,COVID-19感染状态，和疾病活动的变化。结果39例患者纳入研究。其中,26例（66.7%）免疫抑制。37例(94.9%)患者的随访频率发生显著改变(p<0.001):28例(71.8%)患者未就诊,其中26人(92.9%)根本没有交流。10例患者（25.6%）的治疗改变，要么是他们的医生，要么是他们自己。改变自己治疗方法的患者疾病活动重新激活。只有一名患者（2.6%）感染了COVID-19。结论记录这一时期表明，一些患者最初受到大流行的负面影响。最重要的影响因素是患者与医生沟通的中断。
