PDF(Pubmed)
Abstract：
Autoimmune lupus enteritis in systemic lupus erythematosus (SLE) is a rare manifestation that comprises of gastrointestinal tract inflammation with supportive images and/or biopsy findings. We report a unique case of widespread lupus enteritis occurring late in the disease process and in isolation without additional features of active SLE but in the presence of SLE serological activity. There was no clear evidence of active mesenteric vasculitis, intestinal pseudo-obstruction, protein-losing enteropathy, or coagulopathy by imaging or histopathology. This is the first reported case of an SLE patient with pan-gastrointestinal involvement of lupus enteritis responding to Belimumab, with complete resolution of the gastrointestinal syndrome and no further recurrence of gastrointestinal events. Rapid diagnosis and prompt immunomodulatory treatment of lupus-related enteritis are critical to avoid potentially life-threatening complications.
摘要：
系统性红斑狼疮（SLE）中的自身免疫性狼疮肠炎是一种罕见的表现，包括胃肠道炎症，具有支持性图像和/或活检结果。我们报告了一个独特的病例，该病例在疾病过程后期和孤立地发生，没有活动性SLE的其他特征，但存在SLE血清学活性。没有明确的证据表明活动性肠系膜血管炎,肠道假性梗阻,蛋白质丢失性肠病，或影像学或组织病理学显示的凝血病。这是首例报道的SLE患者，对Belimumab有反应的狼疮肠炎的泛胃肠道受累，胃肠道综合征完全缓解，胃肠道事件不再复发。狼疮相关性肠炎的快速诊断和及时免疫调节治疗对于避免潜在的危及生命的并发症至关重要。
