PDF(Pubmed)
Abstract：
UNASSIGNED: A previous study compared insulin sensitivity indices for the detection of double diabetes (DD) in Indian adolescents with type-1 diabetes (T1D) and derived a cut-off to predict future risk for the development of metabolic syndrome (MS) in adolescents with T1D. We conducted the current study with the aim to validate these cut-offs for detecting DD among Indian subjects with T1D from various geographical locations.
UNASSIGNED: This multicentric cross-sectional study included 161 Indian adolescents with T1D. Demographic, anthropometric, clinical, and biochemical data were collected using standard protocols. Insulin sensitivity (IS) was calculated using various equations developed to determine insulin sensitivity in subjects with T1D. Metabolic syndrome was diagnosed using International Diabetes Federation (IDF) Consensus Definition 2017.
UNASSIGNED: We report 4.3% prevalence of MS in Indian adolescents with T1D with an additional 29.8% of study participants at risk of development of MS. Low High density lipoprotein (HDL) (23.6%) was the commonest abnormal component of the MS definition. Insulin sensitivity calculated by an equation derived by the SEARCH group was the most appropriate index to identify MS and metabolic risk in Indian adolescents with T1D. The proposed cut-off of 5.48 had high specificity, positive predictive value, and negative predictive value in identifying the risk of the development of DD.
UNASSIGNED: Insulin sensitivity calculated by the equation proposed by the SEARCH group together with cut-offs derived in earlier study may be used effectively to identify risk of development of MS/DD in Indian adolescents with T1D from various geographical locations.
UNASSIGNED: This multicentric cross-sectional study included 161 Indian adolescents with T1D. Demographic, anthropometric, clinical, and biochemical data were collected using standard protocols. Insulin sensitivity (IS) was calculated using various equations developed to determine insulin sensitivity in subjects with T1D. Metabolic syndrome was diagnosed using International Diabetes Federation (IDF) Consensus Definition 2017.
UNASSIGNED: We report 4.3% prevalence of MS in Indian adolescents with T1D with an additional 29.8% of study participants at risk of development of MS. Low High density lipoprotein (HDL) (23.6%) was the commonest abnormal component of the MS definition. Insulin sensitivity calculated by an equation derived by the SEARCH group was the most appropriate index to identify MS and metabolic risk in Indian adolescents with T1D. The proposed cut-off of 5.48 had high specificity, positive predictive value, and negative predictive value in identifying the risk of the development of DD.
UNASSIGNED: Insulin sensitivity calculated by the equation proposed by the SEARCH group together with cut-offs derived in earlier study may be used effectively to identify risk of development of MS/DD in Indian adolescents with T1D from various geographical locations.
摘要：
■先前的一项研究比较了印度青少年1型糖尿病（T1D）中检测双重糖尿病（DD）的胰岛素敏感性指数，并得出了一个临界值，以预测T1D青少年中代谢综合征（MS）发展的未来风险。我们进行了当前的研究，目的是验证这些截止值，以在来自不同地理位置的T1D印度受试者中检测DD。
■这项多中心横断面研究包括161名患有T1D的印度青少年。人口统计,人体测量学,临床,使用标准方案收集生化数据。使用各种方程式计算胰岛素敏感性(IS)以确定患有T1D的受试者中的胰岛素敏感性。使用2017年国际糖尿病联合会（IDF）共识定义诊断代谢综合征。
我们报告了患有T1D的印度青少年中MS的患病率为4.3％，另外29.8％的研究参与者有发生MS的风险。低高密度脂蛋白（HDL）（23.6％）是MS定义中最常见的异常成分。通过SEARCH组得出的方程计算的胰岛素敏感性是识别患有T1D的印度青少年中MS和代谢风险的最合适指标。建议的截止值5.48具有很高的特异性，正预测值，在识别DD发展风险方面具有阴性预测值。
■通过SEARCH小组提出的公式计算的胰岛素敏感性以及早期研究中得出的截止值可以有效地用于识别来自不同地理位置的T1D印度青少年MS/DD发展的风险。
■这项多中心横断面研究包括161名患有T1D的印度青少年。人口统计,人体测量学,临床,使用标准方案收集生化数据。使用各种方程式计算胰岛素敏感性(IS)以确定患有T1D的受试者中的胰岛素敏感性。使用2017年国际糖尿病联合会（IDF）共识定义诊断代谢综合征。
我们报告了患有T1D的印度青少年中MS的患病率为4.3％，另外29.8％的研究参与者有发生MS的风险。低高密度脂蛋白（HDL）（23.6％）是MS定义中最常见的异常成分。通过SEARCH组得出的方程计算的胰岛素敏感性是识别患有T1D的印度青少年中MS和代谢风险的最合适指标。建议的截止值5.48具有很高的特异性，正预测值，在识别DD发展风险方面具有阴性预测值。
■通过SEARCH小组提出的公式计算的胰岛素敏感性以及早期研究中得出的截止值可以有效地用于识别来自不同地理位置的T1D印度青少年MS/DD发展的风险。
