PDF(Pubmed)
Abstract：
Immunocompromised district refers to the area of the skin with altered immune response predisposing secondary diseases to develop in an immunocompetent individual. This might be explained by the theory of T-cell exhaustion which is characterized by the impairment of the effector function of antigen-specific T cells due to chronic persistence of the primary antigen. T-cell exhaustion model is not well known; however, it serves as a newer concept in the pathogenesis of diseases occurring simultaneously over the same site. Thus, it is not surprising to have two different infectious or non-infectious dermatoses over the same site one preceding the other as observed in our patient. The concept of immunocompromised district and T-cell exhaustion is a rare phenomenon; however, it should be identified by the treating physicians/dermatologists for the optimum management of the atypical presentation of the diseases.
摘要：
免疫受损区域是指具有改变的免疫应答的皮肤区域,其诱发继发性疾病在有免疫能力的个体中发展。这可以通过T细胞耗竭理论来解释，该理论的特征是由于主要抗原的慢性持续存在而导致抗原特异性T细胞的效应子功能受损。T细胞耗竭模型并不为人所知；然而，它是在同一部位同时发生的疾病的发病机理中的一个新概念。因此，在我们的患者中观察到，在同一部位出现两种不同的感染性或非感染性皮肤病，一种在另一种之前，这并不奇怪。免疫受损区和T细胞耗竭的概念是一种罕见的现象；然而，应由治疗医师/皮肤科医生确定，以对疾病的非典型表现进行最佳管理。
