PDF(Pubmed)
Abstract：
In many individuals with a diagnosis of schizophrenia social functioning is impaired across the lifespan. Social cognition has emerged as one of the possible factors that may contribute to these challenges. Neuroimaging research can give further insights into the underlying mechanisms of social (cognitive) difficulties. This review summarises the evidence on the associations between social cognition in the domains of theory of mind and emotion perception and processing, and individuals\' social functioning and social skills, as well as associated neural mechanisms. Eighteen behavioural studies were conducted since the last major review and meta-analysis in the field (inclusion between 7/2017 and 1/2022). No major review has investigated the link between the neural mechanisms of social cognition and their association with social functioning in schizophrenia. Fourteen relevant studies were included (from 1/2000 to 1/2022). The findings of the behavioural studies showed that associations with social outcomes were slightly stronger for theory of mind than for emotion perception and processing. Moreover, performance in both social cognitive domains was more strongly associated with performance on social skill measures than questionnaire-based assessment of social functioning in the community. Studies on the underlying neural substrate of these associations presented mixed findings. In general, higher activation in various regions of the social brain was associated with better social functioning. The available evidence suggests some shared regions that might underlie the social cognition-social outcome link between different domains. However, due to the heterogeneity in approaches and findings, the current knowledge base will need to be expanded before firm conclusions can be drawn.
摘要：
在许多诊断为精神分裂症的个体中，社会功能在整个生命周期中都受到损害。社会认知已成为可能导致这些挑战的可能因素之一。神经影像学研究可以进一步了解社会（认知）困难的潜在机制。这篇综述总结了心理理论与情绪感知和加工领域的社会认知之间关联的证据，和个人的社会功能和社会技能，以及相关的神经机制。自该领域的最后一次主要综述和荟萃分析以来，进行了18项行为研究（纳入2017年7月1日至2022年1月）。尚无主要综述研究精神分裂症中社会认知的神经机制及其与社会功能的关联之间的联系。包括14项相关研究（从2000年1月1日至2022年1月1日）。行为研究的结果表明，心理理论与社会结果的关联比情绪感知和处理的关联略强。此外，与基于问卷的社区社会功能评估相比,两个社会认知领域的表现与社会技能指标的表现更密切相关.对这些关联的潜在神经底物的研究提出了不同的发现。总的来说,在社会大脑的各个区域中更高的激活与更好的社会功能相关。现有证据表明，一些共享区域可能是不同领域之间社会认知-社会结果联系的基础。然而,由于方法和发现的异质性，在得出明确的结论之前，需要扩大当前的知识库。
