PDF(Pubmed)
Abstract：
OBJECTIVE: To prospectively assess the effect of regular application of perfluorohexyloctane (F6H8; Evotears®) on the tear film lipid layer, higher order aberrations (HOA) and the repeatability of measurements in healthy eyes.
METHODS: This prospective clinical study included 104 eyes treated with F6H8 four times daily for four weeks (group A) and 101 eyes that served as controls (group B). Measurements were performed with the WASCA aberrometer (Carl Zeiss Meditec GmbH, Jena, Germany). Main outcome measurement in addition to subjective refraction were the root mean square values of HOA measured before and after the intervention.
RESULTS: Regular use of F6H8 over a period of four weeks significantly increases HOA in healthy eyes (p < 0.05). In addition, the repeatability of measurement increases after the application of F6H8.
CONCLUSIONS: F6H8 may be a suitable treatment option to improve the accuracy of refractive assessment, although it increases HOA. Further studies are needed to confirm the effect on HOA and the repeatability of measurement.
METHODS: This prospective clinical study included 104 eyes treated with F6H8 four times daily for four weeks (group A) and 101 eyes that served as controls (group B). Measurements were performed with the WASCA aberrometer (Carl Zeiss Meditec GmbH, Jena, Germany). Main outcome measurement in addition to subjective refraction were the root mean square values of HOA measured before and after the intervention.
RESULTS: Regular use of F6H8 over a period of four weeks significantly increases HOA in healthy eyes (p < 0.05). In addition, the repeatability of measurement increases after the application of F6H8.
CONCLUSIONS: F6H8 may be a suitable treatment option to improve the accuracy of refractive assessment, although it increases HOA. Further studies are needed to confirm the effect on HOA and the repeatability of measurement.
摘要：
目的：前瞻性评估定期应用全氟己基辛烷（F6H8；Evotears®）对泪膜脂质层的影响，高阶像差(HOA)和健康眼睛测量的可重复性。
方法：这项前瞻性临床研究包括104只眼，每天4次F6H8治疗4周（A组）和101只眼作为对照（B组）。用WASCA像差仪(CarlZeissMeditecGmbH，Jena,德国)。除主观屈光外，主要结果测量是干预前后测量的HOA均方根值。
结果：在4周内定期使用F6H8可显著增加健康眼睛的HOA（p<0.05）。此外,应用F6H8后，测量的重复性增加。
结论：F6H8可能是提高屈光评估准确性的合适治疗选择，虽然它增加了HOA。需要进一步的研究来证实对HOA的影响和测量的可重复性。
方法：这项前瞻性临床研究包括104只眼，每天4次F6H8治疗4周（A组）和101只眼作为对照（B组）。用WASCA像差仪(CarlZeissMeditecGmbH，Jena,德国)。除主观屈光外，主要结果测量是干预前后测量的HOA均方根值。
结果：在4周内定期使用F6H8可显著增加健康眼睛的HOA（p<0.05）。此外,应用F6H8后，测量的重复性增加。
结论：F6H8可能是提高屈光评估准确性的合适治疗选择，虽然它增加了HOA。需要进一步的研究来证实对HOA的影响和测量的可重复性。
