Abstract：
The effects of oral dexamethasone on peripheral nerve blocks have not been investigated. We randomly allocated adults scheduled for forearm or hand surgery to oral placebo (n = 61), dexamethasone 12 mg (n = 61) or dexamethasone 24 mg (n = 57) about 45 min before lateral infraclavicular block. Mean (SD) time until first pain after block were: 841 (327) min; 1171 (318) min; and 1256 (395) min, respectively. Mean (98.3%CI) differences in time until first postoperative pain for dexamethasone 24 mg vs. placebo and vs. dexamethasone 12 mg were: 412 (248-577) min, p < 0.001; and 85 (-78 to 249) min, p = 0.21, respectively. Mean (98.3%CI) difference in time until first postoperative pain for dexamethasone 12 mg vs. placebo was 330 (186-474) min, p < 0.001. Both 24 mg and 12 mg of oral dexamethasone increased the time until first postoperative pain compared with placebo in patients having upper limb surgery under infraclavicular brachial plexus block.
摘要：
尚未研究口服地塞米松对周围神经阻滞的影响。我们将计划进行前臂或手部手术的成年人随机分配给口服安慰剂（n=61），地塞米松12mg（n=61）或地塞米松24mg（n=57）约45分钟前锁骨下外侧阻滞。直到阻滞后第一次疼痛的平均（SD）时间为：841（327）分钟;1171（318）分钟;和1256（395）分钟，分别。地塞米松24mg与24mg与24mg的平均（98.3CI）在术后第一次疼痛之前的时间差异安慰剂和vs.地塞米松12毫克为：412（248-577）分钟，p<0.001；和85（-78至249）分钟，分别为p=0.21。地塞米松12mg与第一次术后疼痛的平均（98.3CI）差异安慰剂为330（186-474）分钟，p<0.001。在锁骨下臂丛神经阻滞下进行上肢手术的患者中，与安慰剂相比，24mg和12mg口服地塞米松均增加了直到术后第一次疼痛的时间。
