Abstract：
Coronavirus disease 2019 (COVID-19) remains a health problem worldwide. The present study aimed to investigate the effect of blood pressure (BP) on the circadian pattern and prevalence of new-onset non-dipper hypertension in the post-COVID period in patients with known hypertension. This prospective single-center study included 722 patients hospitalized for COVID-19 infection. Ambulatory BP (ABP) data were collected during their initial hospitalization. The ABP data were reassessed 1 month after the patients were discharged. The results were compared with a healthy control group with known hypertension but without COVID-19 infection. After exclusion criteria were applied, the study included 187 patients with COVID-19 and 136 healthy hypertensive controls. Post-COVID ABP showed that patients with COVID-19 had significantly higher mean 24-h systolic and diastolic BP, mean nighttime systolic and diastolic BP, and mean daytime diastolic BP than the control group. In addition, new-onset non-dipper hypertension was significantly higher in patients with COVID-19. This study demonstrated for the first time that the circadian pattern is disturbed and a non-dipper pattern develops in individuals with known hypertension during the post-COVID period.
摘要：
2019年冠状病毒病（COVID-19）仍然是全球的健康问题。本研究旨在调查已知高血压患者在COVID后时期血压（BP）对新发非斗型高血压的昼夜节律模式和患病率的影响。这项前瞻性单中心研究包括722例因COVID-19感染住院的患者。在初次住院期间收集动态血压（ABP）数据。患者出院后1个月重新评估ABP数据。将结果与已知高血压但没有COVID-19感染的健康对照组进行比较。应用排除标准后，这项研究纳入了187例COVID-19患者和136例健康高血压对照.COVID后ABP显示，COVID-19患者的平均24小时收缩压和舒张压明显升高，平均夜间收缩压和舒张压血压，和平均日间舒张压比对照组高。此外,COVID-19患者的新发非斗型高血压明显升高.这项研究首次表明，在COVID后时期，已知高血压的个体的昼夜节律模式受到干扰，并且出现了非北斗星模式。
