Abstract：
This study aimed to review the current knowledge on sexual dysfunction in men and women with hyperthyroidism through a systematic review and meta-analysis. Available clinical trials from the MEDLINE database were searched using a prerecorded protocol (Protocol Prospero ID: CRD42022340587), and obtained data were analyzed and reported according to the PRISMA guidelines. Pooled effect estimates were computed using a random-effects model. Twenty eligible studies were identified, of which 15 were included in this meta-analysis. The prevalence of erectile dysfunction was significantly higher in participants with hyperthyroidism than that in controls [odds ratio = 9.16 (95% confidence interval [CI], 5.0-16.5)]. Treatment of hyperthyroidism alone improved erectile functions [effect size, ES = 0.36 (95% CI, -0.01-72)] and mean intra-vaginal ejaculation latency time [ES = 0.63 (95% CI, 0.27-98)] among men with erectile dysfunction and/or premature ejaculation. The prevalence of premature ejaculation also decreased with treatment of hyperthyroidism [odds ratio = 0.11 (95% CI, 0.04-28). Women with hyperthyroidism demonstrated higher odds in female sexual dysfunction than controls [odds ratio = 4.34 (95% CI, 2.63-7.18)]. Female sexual function index scores in women with hyperthyroidism were also significantly lower than those in the controls with moderate effect sizes. An evident and reversible disruption of sexual functions under hyperthyroidism conditions was observed in both sexes.
摘要：
本研究旨在通过系统评价和荟萃分析，回顾男性和女性甲状腺功能亢进患者性功能障碍的最新知识。使用预先记录的协议（ProtocolProsperoID：CRD420223440587）搜索MEDLINE数据库中的可用临床试验，和获得的数据根据PRISMA指南进行分析和报告.集合效应估计是使用随机效应模型计算的。确定了20项符合条件的研究，其中15项纳入本荟萃分析.甲状腺功能亢进患者勃起功能障碍的患病率明显高于对照组[比值比=9.16(95%置信区间[CI],5.0-16.5)].单独治疗甲状腺功能亢进可改善勃起功能[效应大小，在勃起功能障碍和/或早泄的男性中，ES=0.36（95％CI，-0.01-72）]和平均阴道射精潜伏期[ES=0.63（95％CI，0.27-98）]。甲亢治疗后早泄的患病率也降低[比值比=0.11(95%CI,0.04-28)。甲状腺功能亢进的女性性功能障碍发生率高于对照组[比值比=4.34(95%CI,2.63-7.18)]。甲状腺功能亢进女性的女性性功能指数评分也显着低于中等效应大小的对照组。在两种性别中都观察到甲状腺功能亢进条件下性功能的明显可逆破坏。
