PDF(Pubmed)
Abstract：
We investigated the neurological effects of the varied erinacine composition of different mycelia cultures in mice with trimethyltin (TMT)-induced neurodegeneration. Forty male ICR mice were randomly divided into five groups of Sham-veh, TMT-veh, TMT-EME, TMT-EMR and TMT-EME/R. The TMT groups received 2.6 mg/kg one-time intraperitoneal injections of TMT. Oral dosages of 200 mg/kg erinacine combination from each Hericium erinaceus mycelia (EM) cultivated formula (100% eucalyptus wood [E], 100% rubber wood [R], or 40% eucalyptus wood/60% rubber wood [E/R]) were given for two weeks. Spatial learning, memory, flexibility, and anxious behaviour were evaluated alongside brain tissues\' oxidative status and histological analyses. Erinacine composition from EME/R exhibited significant positive effects on spatial learning, memory, flexibility, and anxiety (p < 0.05). These findings emerged concurrently with the significant mitigation of hippocampal lipid peroxidation, CA1 hippocampal, cortical neuron, and corpus callosum white matter degeneration (p < 0.05). These neurological benefits were associated with the EME/R composition of erinacine A, C, D, G, H, I, K and R. The best neuroprotective effect against TMT-induced neurodegeneration in mice is offered by the EME/R erinacine composition according to its anti-lipid peroxidation, its nurturing effect on neuronal and white matter, and mitigation of behavioural deficits.
摘要：
我们研究了三甲基锡（TMT）诱导的神经变性小鼠中不同菌丝体培养物的不同雌蕊组成的神经系统作用。40只雄性ICR小鼠随机分为5组,TMT-veh,TMT-EME,TMT-EMR和TMT-EME/RTMT组接受2.6mg/kg一次性腹膜内注射TMT。从每种猴头菌菌丝体（EM）栽培配方中口服200mg/kg的赤子碱组合（100％桉树木[E]，100%橡胶木[R],或给予40%桉树木/60%橡胶木[E/R])两周。空间学习,记忆,灵活性,与脑组织氧化状态和组织学分析一起评估焦虑行为。EME/R的Erinacine成分对空间学习表现出显着的积极影响，记忆,灵活性,和焦虑(p<0.05)。这些发现与海马脂质过氧化的显著缓解同时出现，CA1海马，皮质神经元,和call体白质变性（p<0.05）。这些神经益处与EME/R组成的erinacineA，C,D,G,H,I,K和R。EME/Rerinacine组合物根据其抗脂质过氧化作用，对TMT诱导的小鼠神经变性具有最佳的神经保护作用，它对神经元和白质的滋养作用，和减轻行为缺陷。
