PDF(Pubmed)
Abstract：
Gastric cancer is one of the leading causes of cancer-related deaths across the world and in the Middle East. Human epidermal growth factor receptor 2 (HER2) overexpression has been observed in gastric cancers. Trastuzumab, a recombinant monoclonal antibody targeting HER2 protein, is being used for treatment of metastatic gastric cancer. To study the frequency and association of HER2 overexpression with age, gender, histopathological subtype and grade of differentiation in patients with gastric adenocarcinoma from Basra, Iraq. This cross-sectional single-center study collected demographic (age, gender), histopathological (histological subtype, grade of differentiation) and immunohistochemical (HER2 overexpression status) data from 100 consenting adult patients (male: 56) with histopathologically confirmed gastric adenocarcinoma from samples obtained through endoscopy or surgery. HER2 overexpression (ToGA score 3+) was observed in 6/100 (6%) of patients, with another 6 showing \'equivocal\' HER2 expression (2+). Out of 20 patients with moderately differentiated gastric cancer, 4 (20%) showed HER2 overexpression (p=0.008). Other factors considered (age, gender, histological subtype) did not show statistically significant correlation with HER2 overexpression. More females showed HER2 overexpression than males (4 vs. 2), and more patients with intestinal type gastric cancer showed HER2 overexpression than diffuse gastric cancer (5 vs. 1), but the difference was not statistically significant in both variables. HER2 overexpression was 6% in this population; statistically significant correlation was found with histological grade. Statistically non-significant correlations were observed between HER2 overexpression and gender, age, and histological subtype.
摘要：
胃癌是全球和中东癌症相关死亡的主要原因之一。在胃癌中观察到人表皮生长因子受体2（HER2）过表达。曲妥珠单抗,针对HER2蛋白的重组单克隆抗体，用于治疗转移性胃癌.为了研究HER2过表达的频率及其与年龄的相关性，性别,来自巴士拉的胃腺癌患者的组织病理学亚型和分化程度，伊拉克。这项横断面单中心研究收集了人口学(年龄，性别)，组织病理学（组织学亚型，分化等级）和免疫组织化学（HER2过表达状态）数据来自100例同意的成年患者（男性：56），这些患者的组织病理学证实为胃腺癌，这些患者来自通过内窥镜或手术获得的样本。在6/100（6％）的患者中观察到HER2过表达（ToGA评分3+），另外6个显示“模棱两可”的HER2表达（2+）。在20例中分化胃癌患者中，图4(20%)显示HER2过表达(p=0.008)。考虑的其他因素(年龄，性别,组织学亚型）与HER2过表达无统计学意义。更多的女性显示HER2过度表达比男性（4对2),与弥漫性胃癌相比，肠型胃癌患者更多的HER2过表达（5vs.1),但两个变量的差异均无统计学意义.在该人群中HER2过表达为6％；发现与组织学分级具有统计学意义的相关性。在HER2过表达和性别之间观察到统计学上的非显著相关性,年龄,和组织学亚型。
