PDF(Pubmed)
Abstract：
Insulin resistance (IR) and cardiovascular diseases (CVD) are relevant concerns in the elderly population; as the world\'s population ages, IR and CVD are two universal public health problems. While a link between IR a CVD has been established, the mediating mechanisms are uncertain and rigorous investigations are needed to fully elucidate them. The study aimed at assessing the relationship between epicardial fat (EF), an indicator of cardiovascular risk, and IR in Italian free-living elderly (n = 89). Baseline data from a previous cohort was used. Anthropometric measurements, EF, and IR-related variables, including the HOMA-IR index and other biochemical parameters were obtained. The correlation between EF and IR was explored. Further analysis was conducted to identify significant differences regarding IR variables among EF quartiles. EF correlated positively with glucose levels in females, males and the total population. The pairwise comparison among EF quartiles showed significant differences in glucose levels, HOMA-IR index, triglycerides, and total cholesterol levels. To our knowledge, this is the only study assessing the relationship between EF and IR in healthy elderly, while most of the studies have investigated EF and IR in diseased populations. Further research with a longitudinal approach should be conducted to design concrete conclusions about this relationship.
摘要：
胰岛素抵抗(IR)和心血管疾病(CVD)是老年人群的相关问题,IR和CVD是两个普遍的公共卫生问题。虽然已经建立了IR一CVD之间的联系，调解机制尚不确定,需要进行严格的调查才能充分阐明.该研究旨在评估心外膜脂肪（EF）之间的关系，心血管风险的指标，意大利自由生活老年人的IR（n=89）。使用来自先前队列的基线数据。人体测量,EF,和IR相关变量，获得了包括HOMA-IR指数和其他生化参数。探讨了EF与IR之间的相关性。进行了进一步的分析，以确定EF四分位数之间IR变量的显着差异。EF与女性的血糖水平呈正相关，男性和总人口。EF四分位数之间的成对比较显示葡萄糖水平的显着差异，HOMA-IR指数，甘油三酯，和总胆固醇水平。据我们所知,这是唯一一项评估健康老年人EF和IR之间关系的研究，虽然大多数研究调查了患病人群的EF和IR。应进行纵向方法的进一步研究，以设计有关这种关系的具体结论。
