PDF(Pubmed)
Abstract：
UNASSIGNED: Odontogenic cysts and tumours are a wide array of complex pathological entities ranging from mild indolent to aggressive detrimental in nature, which occur as a result of anomalous alterations in normal odontogenesis. Hence, these odontogenic lesions need to be evaluated extensively by using potential immunohistochemical markers.
UNASSIGNED: To evaluate and compare the expression of podoplanin, a lymphoendothelial IHC marker in odontogenic cysts and odontogenic tumours to determine their proliferative potential.
UNASSIGNED: All the study samples were retrieved from the archives of the Department of Oral Pathology and Microbiology, PIDS&RC, Hyderabad. The study samples were selected as per the standard histopathological diagnostic criteria and subjected for IHC analysis using podoplanin.
UNASSIGNED: Seventy paraffin-embedded tissue specimens of OKC, OOC, dentigerous cyst (DC) and ameloblastoma (AM) include study sample, which were stained with podoplanin IHC marker and staining properties were evaluated. All the cases were categorized as high, moderate, weak or negatively reactive on the basis of the composite scoring.
UNASSIGNED: Statistical analysis was done using SPSS version 14, and then results were compared by ANOVA post hoc test and Kruskal Wallis Test.
UNASSIGNED: In the comparison of composite scores of OKCs and AM, there was no significant statistical difference.
UNASSIGNED: The present study contributes to the significant association of podoplanin expression with cellular proliferation, cystic expansion and local invasiveness of odontogenic cysts and tumours through cytoskeletal reorganization and cell migration.
UNASSIGNED: To evaluate and compare the expression of podoplanin, a lymphoendothelial IHC marker in odontogenic cysts and odontogenic tumours to determine their proliferative potential.
UNASSIGNED: All the study samples were retrieved from the archives of the Department of Oral Pathology and Microbiology, PIDS&RC, Hyderabad. The study samples were selected as per the standard histopathological diagnostic criteria and subjected for IHC analysis using podoplanin.
UNASSIGNED: Seventy paraffin-embedded tissue specimens of OKC, OOC, dentigerous cyst (DC) and ameloblastoma (AM) include study sample, which were stained with podoplanin IHC marker and staining properties were evaluated. All the cases were categorized as high, moderate, weak or negatively reactive on the basis of the composite scoring.
UNASSIGNED: Statistical analysis was done using SPSS version 14, and then results were compared by ANOVA post hoc test and Kruskal Wallis Test.
UNASSIGNED: In the comparison of composite scores of OKCs and AM, there was no significant statistical difference.
UNASSIGNED: The present study contributes to the significant association of podoplanin expression with cellular proliferation, cystic expansion and local invasiveness of odontogenic cysts and tumours through cytoskeletal reorganization and cell migration.
摘要：
■牙源性囊肿和肿瘤是一系列复杂的病理实体，从轻度惰性到侵袭性有害，这是正常牙本质发育异常改变的结果。因此，这些牙源性病变需要通过使用潜在的免疫组织化学标记进行广泛评估。
■要评估和比较podoplanin的表达，牙源性囊肿和牙源性肿瘤中的淋巴内皮IHC标记物，用于确定其增殖潜力。
■所有研究样本均从口腔病理学和微生物学系的档案中检索，PIDS和RC，海得拉巴.根据标准组织病理学诊断标准选择研究样品,并使用Podoplanin进行IHC分析。
■70个石蜡包埋的OKC组织标本，OOC,牙质囊肿（DC）和成釉细胞瘤（AM）包括研究样本，用PodoplaninIHC标记物染色，并评估染色特性。所有病例都被归类为高，中度,弱或负反应的基础上的复合评分。
■使用SPSS版本14进行统计分析，然后通过ANOVA事后检验和KruskalWallis检验比较结果。
■在OKC和AM的综合得分比较中，差异无统计学意义。
■本研究有助于podoplanin表达与细胞增殖的显着关联，通过细胞骨架重组和细胞迁移，牙源性囊肿和肿瘤的囊性扩张和局部侵袭。
■要评估和比较podoplanin的表达，牙源性囊肿和牙源性肿瘤中的淋巴内皮IHC标记物，用于确定其增殖潜力。
■所有研究样本均从口腔病理学和微生物学系的档案中检索，PIDS和RC，海得拉巴.根据标准组织病理学诊断标准选择研究样品,并使用Podoplanin进行IHC分析。
■70个石蜡包埋的OKC组织标本，OOC,牙质囊肿（DC）和成釉细胞瘤（AM）包括研究样本，用PodoplaninIHC标记物染色，并评估染色特性。所有病例都被归类为高，中度,弱或负反应的基础上的复合评分。
■使用SPSS版本14进行统计分析，然后通过ANOVA事后检验和KruskalWallis检验比较结果。
■在OKC和AM的综合得分比较中，差异无统计学意义。
■本研究有助于podoplanin表达与细胞增殖的显着关联，通过细胞骨架重组和细胞迁移，牙源性囊肿和肿瘤的囊性扩张和局部侵袭。
