PDF(Pubmed)
Abstract：
We assessed changes in gray matter volume (GMV) of nine subcortical regions (accumbens, amygdala, brainstem, caudate, cerebellar cortex, pallidum, putamen, thalamus, and ventral diencephalon) across the lifespan in a large sample of participants in the Human Connectome Project (n = 2,458, 5-90 yr old, 1,113 males and 1,345 females). 3T MRI data were acquired using a harmonized protocol and were processed in an identical way for all brains. GMVs of individual regions were adjusted for estimated total intracranial volume and regressed against age. We found highly statistically significant changes in GMV with age (P < 0.001) that were distinct among areas and mostly consistent between sexes, as follows. 1) The GMVs of accumbens, caudate, putamen, and cerebellum decreased with age in a linear fashion. The rate of decrease was steeper in males than in females for all regions. 2) The GMVs of the amygdala, pallidum, thalamus, ventral diencephalon, and brainstem changed with age in a quadratic fashion, i.e., increasing first and decreasing afterward. The estimated age at the peak (vertex) of the parabola was 51.8 yr for the brainstem and 28.0-37.9 yr for the other regions. The peak occurred earlier in males than in females, by an average of 8 yr, with the exception of the brainstem, where the age at the peak was very similar in both sexes. These results confirm previous findings and offer new insights into region-specific age-related changes in subcortical brain GMVs.NEW & NOTEWORTHY We report mixed effects of age on subcortical grey matter volume (GMV) during lifespan (n = 2458, 5-90 yr old, 1113 male, 1345 female). Striatal and cerebellar GMVs decreased linearly with age, more steeply in males. In contrast, GMVs of the amygdala, pallidum, thalamus, ventral diencephalon, and brainstem changed in a quadratic fashion, increasing first and decreasing afterward, with males peaking earlier than females in all regions but the brainstem where they peaked at nearly the same time.
摘要：
我们评估了9个皮质下区域（伏隔，杏仁核,脑干,尾状,小脑皮质,苍白球,壳核,丘脑,腹侧间脑)在人类连接体项目的大量参与者中的整个寿命(n=2458，5-90岁，1113雄性和1345雌性）。使用协调方案获取3TMRI数据，并以相同的方式对所有大脑进行处理。根据估计的总颅内体积调整各个区域的GMV，并根据年龄进行回归。我们发现GMV随年龄的变化具有高度统计学意义（P<0.001），这些变化在地区之间是不同的，并且在性别之间大多是一致的。如下。(a)伏隔的GMV，尾状,壳核和小脑随年龄呈线性下降。在所有地区，男性的下降速度都比女性的下降速度更快。(b)杏仁核的GMV,苍白球,丘脑,腹侧间脑和脑干随着年龄的增长呈二次变化，即先增加后减少。对于脑干，抛物线峰值（顶点）的估计年龄为51.8岁，其他地区为28.0-37.9。高峰发生在男性比女性更早，平均8年，除了脑干,男女的高峰年龄非常相似。这些结果证实了先前的发现，并为皮质下脑GMV中特定区域与年龄相关的变化提供了新的见解。
