Abstract：
Renomegaly has been reported in dogs with congenital portosystemic shunts (PSS). However, no study has objectively evaluated the degree of renomegaly in dogs with different types of PSS. The purpose of this retrospective, analytical, cross-sectional study was to determine kidney size (renal length-to-L2 vertebral body ratio; RL/L2 ratio) using CT in dogs with different types of PSS and correlate with clinical information. A medical record search for dogs with a PSS diagnosed using CT between 2016 and 2020 was conducted. Breed, age, sex, body weight, and biochemistry results were recorded. Kidney and L2 vertebral body lengths were measured using multiplanar reformatted CT images, and the RL/L2 ratio was calculated. Dogs were categorized into four groups based on PSS morphology for comparisons: intrahepatic (IH; n = 19), extrahepatic portocaval (EHPC; n = 20), extrahepatic portoazygos (EHPA; n = 7), or extrahepatic portophrenic (EHPP, n = 7). The RL/L2 ratio (mean ± SD) was largest in IH (3.55 ± 0.38) and EHPC (3.55 ± 0.38), followed by EHPP (3.10 ± 0.23), and EHPA (2.78 ± 0.18). RL/L2 ratio was significantly larger in EHPC and IH (vs. EHPA and EHPP [P < .01]). Significant correlations between kidney size and creatinine, alkaline phosphatase, albumin, total protein, and ammonia were present. Renomegaly was observed in 86.8% of dogs with PSS overall, but it was uncommon in dogs with EHPA and less common in dogs with EHPP, as these two groups showed clinical signs later in life, made evident by older age at presentation. The authors suggest that the severity of hepatic dysfunction and the shunted blood volume may influence the development of renomegaly in dogs with PSS.
摘要：
据报道，患有先天性门体分流（PSS）的狗有肾肿大。然而,没有研究客观评估不同类型PSS犬的肾肿大程度。这次回顾的目的，分析，横断面研究是使用CT在具有不同类型PSS的狗中确定肾脏大小（肾脏长度与L2椎体之比；RL/L2比），并与临床信息相关。对2016年至2020年间使用CT诊断出PSS的狗进行了医疗记录搜索。品种，年龄,性别,体重,并记录生化结果。使用多平面重新格式化的CT图像测量肾脏和L2椎体长度，并计算RL/L2比率。根据PSS形态学将狗分为四组进行比较：肝内（IH;n=19），肝外门腔（EHPC；n=20），肝外口齿菌（EHPA；n=7），或肝外门脉（EHPP，n=7)。RL/L2比值（平均值±SD）在IH（3.55±0.38）和EHPC（3.55±0.38）中最大，其次是EHPP（3.10±0.23），和EHPA（2.78±0.18）。EHPC和IH的RL/L2比率明显更大（与EHPA和EHPP[P<0.01])。肾脏大小和肌酐之间存在显著相关性，碱性磷酸酶,白蛋白,总蛋白质，和氨存在。在总体上有PSS的狗中，有86.8％观察到肾肿大，但在EHPA的狗中并不常见，在EHPP的狗中并不常见，因为这两组在以后的生活中表现出临床症状，在演讲中表现得很明显。作者认为，肝功能障碍的严重程度和分流的血容量可能会影响PSS犬的肾肿大的发展。
