METHODS: We comprehensively analyzed differential levels of USFs expression, genomic alteration, DNA methylation, and their prognostic value across different cancer types and the possible correlation with tumor-infiltrating immune cells and drug response by using different bioinformatics tools.
RESULTS: Our findings established that USFs play an important role in cancers related to the urinary system and justify the necessity for further investigation. We implemented and offer a useful ShinyApp to facilitate researchers\' efforts to inquire about any other gene of interest and to perform the analysis of drug response in a user-friendly fashion at http://zzdlab.com:3838/Drugdiscovery/.
方法:我们综合分析了USF表达的差异水平,基因组改变,DNA甲基化,通过使用不同的生物信息学工具,以及它们在不同癌症类型中的预后价值,以及与肿瘤浸润免疫细胞和药物反应的可能相关性。
结果:我们的发现证实了USF在与泌尿系统相关的癌症中起着重要作用,并证明了进一步研究的必要性。我们在http://zzdlab.com:3838/Drugdiscovery/上实施并提供有用的ShinyApp,以方便的方式帮助研究人员查询任何其他感兴趣的基因,并以用户友好的方式进行药物反应分析。