Abstract：
Ferroptosis is a novel mechanism of programmed cell death characterized by an iron overload-induced lipid peroxidation cascade. The incidence of alcoholic liver disease (ALD) is rising globally, contributing to markedly high morbidity and mortality. ALD pathogenesis is an intricate and continuously evolving process. Several basic and clinical investigations have established a correlation between ferroptosis and ALD initiation and progression. Additionally, anti-ferroptosis drugs have demonstrated effectiveness in ameliorating alcohol-induced liver injury. This review aims to provide an overview of recent advancements in ferroptosis research pertaining to ALD, encompassing imbalance of antioxidant systems, iron overload, autophagy, mitochondria, epigenetic changes, and prospective therapeutic drugs targeting ferroptosis. Our aim is to reveal the potential of ferroptosis-related diagnoses and therapeutic interventions for the treatment of ALD.
摘要：
铁凋亡是以铁过载诱导的脂质过氧化级联为特征的程序性细胞死亡的新机制。酒精性肝病（ALD）的发病率在全球范围内呈上升趋势，导致明显的高发病率和高死亡率。ALD发病机制是一个复杂且不断发展的过程。一些基础和临床研究已经建立了铁性凋亡与ALD开始和进展之间的相关性。此外,抗铁凋亡药物已证明可有效改善酒精诱导的肝损伤。这篇综述旨在概述与ALD有关的铁沉积研究的最新进展，包括抗氧化系统的不平衡，铁过载，自噬,线粒体,表观遗传变化,以及针对铁凋亡的前瞻性治疗药物。我们的目的是揭示与铁蛋白相关的诊断和治疗性干预措施在ALD治疗中的潜力。
