Abstract：
As bioactive molecules, peptides and proteins are essential in living organisms, including animals and humans. Defects in their function lead to various diseases in humans. Therefore, the use of proteins in treating multiple diseases, such as cancers and hepatitis, is increasing. There are different routes to administer proteins, which have limitations due to their large and hydrophilic structure. Another limitation is the presence of biological and lipophilic membranes that do not allow proteins to pass quickly. There are different strategies to increase the absorption of proteins from these biological membranes. One of these strategies is to use compounds as absorption enhancers. Absorption enhancers are compounds such as surfactants, phospholipids and cyclodextrins that increase protein passage through the biological membrane and their absorption by different mechanisms. This review focuses on using other absorption enhancers and their mechanism in protein administration routes.
摘要：
作为生物活性分子，肽和蛋白质在生物体中是必需的，包括动物和人类。其功能缺陷导致人类的各种疾病。因此,使用蛋白质治疗多种疾病，比如癌症和肝炎，正在增加。有不同的途径来管理蛋白质，由于其大且亲水的结构而具有局限性。另一个限制是不允许蛋白质快速通过的生物和亲脂性膜的存在。有不同的策略来增加蛋白质从这些生物膜的吸收。这些策略之一是使用化合物作为吸收促进剂。吸收促进剂是化合物，如表面活性剂，磷脂，和环糊精，通过不同的机制增加蛋白质通过生物膜和它们的吸收。本文重点介绍了其他吸收促进剂的使用及其在蛋白质给药途径中的作用机制。
