PDF(Pubmed)
Abstract：
Renal cell carcinoma (RCC) is characterized by the development of kidney masses, which can lead to various long-term complications. Among the extrarenal manifestations associated with RCC, the formation of a thrombus within the inferior vena cava (IVC) is particularly prevalent due to the substantial tumor burden imposed by the kidneys. In this report, we present an exceptional case involving an 80-year-old male patient who presented with an intravascular thrombus within the inferior vena cava (IVC), which originated from RCC. The diagnosis of RCC was conclusively established through core needle biopsy and subsequent tumor marker staining. Remarkably, despite the confirmation of RCC within the IVC thrombus through biopsy and tumor marker analysis, radiological assessments failed to reveal any discernible renal cell masses within the kidneys. The patient subsequently received treatment for RCC with a combination regimen of cabozantinib and nivolumab, which resulted in a noteworthy improvement in his clinical condition. The presentation of RCC in this report is notably atypical, given that the biopsy of the thrombus yielded definitive evidence of RCC while radiological investigations did not yield any indications of renal masses or a tumor burden within the kidneys that would typically be associated with RCC.
摘要：
肾细胞癌（RCC）的特征是肾脏肿块的发展，这可能导致各种长期并发症。在与RCC相关的肾外表现中，由于肾脏施加的大量肿瘤负荷,下腔静脉(IVC)内血栓的形成尤其普遍。在这份报告中,我们介绍了一例特殊病例，涉及一名80岁的男性患者，他在下腔静脉（IVC）内出现血管内血栓，起源于RCC。肾癌的诊断是通过芯针活检和随后的肿瘤标志物染色确定的。值得注意的是,尽管通过活检和肿瘤标志物分析证实了IVC血栓内的RCC，放射学评估未能发现肾脏内任何可辨别的肾细胞肿块。患者随后接受了Cabozantinib和nivolumab联合治疗RCC，这导致了他的临床状况的显著改善。本报告中对碾压混凝土的介绍非常不典型，考虑到血栓活检提供了RCC的明确证据,而放射学检查没有发现任何通常与RCC相关的肾脏肿块或肾脏内肿瘤负荷的迹象.
