PDF(Pubmed)
Abstract：
Uveitis is a common ophthalmic diagnosis in cats, that can lead to discomfort and loss of vision. Identification of nonidiopathic cases facilitates treatment and could reduce morbidity associated with this condition.
To evaluate etiologies of nontraumatic uveitis in the UK, to compare diagnostic features between idiopathic cases and those with an established underlying etiology, and to investigate the association of clinical signs and abnormal diagnostic findings with a confirmed etiology.
Records of cats diagnosed with uveitis at a UK referral center between August 2009 and April 2018 were retrospectively reviewed, excluding traumatic (and reflex) cases. Cases were categorized based on whether an underlying etiology had been established in cases with confirmed etiology, idiopathic, and inconclusive cases. All cases had a minimum of 12-month follow-up unless an underlying etiology had been established. Population characteristics, clinical signs, diagnostic investigation features, and results were reported.
72 cases of uveitis were included, of which male cats and domestic breeds were overrepresented. An underlying etiology was determined in 23.6% of cases: 9.7% had infectious diseases, 5.6% had systemic neoplasia, 4.2% had primary ocular neoplasia, and 4.2% had metabolic disease. Idiopathic uveitis comprised 37.5% of cases, and the remaining 38.9% were inconclusive, of which 35.7% died or were euthanased within the follow-up period. Among the study population, no significant age difference was found between cats with idiopathic disease or confirmed etiology. The unilateral disease was reported in 56.9% of cases and was not different across the idiopathic cases and confirmed etiology groups. The most common ophthalmic clinical sign was an aqueous flare, followed by keratic precipitates and hypotony. Iris color change (p = 0.015) and the presence of an intraocular mass (p = 0.025) were associated with an underlying etiology.
Idiopathic uveitis was found to be the most common diagnosis in this study population. However, a similar proportion of cases had possible underlying etiologies as a high proportion manifested systemic disease within the follow-up time. An underlying etiology could be established only in a quarter of cases. Further studies are required to standardize the investigations required when assessing cats with uveitis to minimize patient morbidity.
To evaluate etiologies of nontraumatic uveitis in the UK, to compare diagnostic features between idiopathic cases and those with an established underlying etiology, and to investigate the association of clinical signs and abnormal diagnostic findings with a confirmed etiology.
Records of cats diagnosed with uveitis at a UK referral center between August 2009 and April 2018 were retrospectively reviewed, excluding traumatic (and reflex) cases. Cases were categorized based on whether an underlying etiology had been established in cases with confirmed etiology, idiopathic, and inconclusive cases. All cases had a minimum of 12-month follow-up unless an underlying etiology had been established. Population characteristics, clinical signs, diagnostic investigation features, and results were reported.
72 cases of uveitis were included, of which male cats and domestic breeds were overrepresented. An underlying etiology was determined in 23.6% of cases: 9.7% had infectious diseases, 5.6% had systemic neoplasia, 4.2% had primary ocular neoplasia, and 4.2% had metabolic disease. Idiopathic uveitis comprised 37.5% of cases, and the remaining 38.9% were inconclusive, of which 35.7% died or were euthanased within the follow-up period. Among the study population, no significant age difference was found between cats with idiopathic disease or confirmed etiology. The unilateral disease was reported in 56.9% of cases and was not different across the idiopathic cases and confirmed etiology groups. The most common ophthalmic clinical sign was an aqueous flare, followed by keratic precipitates and hypotony. Iris color change (p = 0.015) and the presence of an intraocular mass (p = 0.025) were associated with an underlying etiology.
Idiopathic uveitis was found to be the most common diagnosis in this study population. However, a similar proportion of cases had possible underlying etiologies as a high proportion manifested systemic disease within the follow-up time. An underlying etiology could be established only in a quarter of cases. Further studies are required to standardize the investigations required when assessing cats with uveitis to minimize patient morbidity.
摘要：
■葡萄膜炎是猫常见的眼科诊断，会导致不适和视力丧失。识别非特发性病例有助于治疗，并可以降低与这种情况相关的发病率。
■为了评估英国非创伤性葡萄膜炎的病因，为了比较特发性病例和具有既定潜在病因的病例之间的诊断特征，并研究临床体征和异常诊断结果与明确病因的关系。
2009年8月至2018年4月在英国转诊中心诊断为葡萄膜炎的猫的记录进行了回顾性回顾。排除创伤性（和反射）病例。根据在确诊病因的病例中是否已确定潜在病因对病例进行分类。特发性,和不确定的案件。除非已经确定了潜在的病因，否则所有病例都至少进行了12个月的随访。人口特征,临床体征,诊断调查功能，并报告了结果。
■包括72例葡萄膜炎，其中雄性猫和家养品种的比例过高。在23.6％的病例中确定了潜在的病因：9.7％患有传染病，5.6%有全身性肿瘤,4.2%有原发性眼肿瘤，4.2%有代谢性疾病。特发性葡萄膜炎占病例的37.5%，其余38.9%没有定论,其中35.7%在随访期内死亡或安乐死。在研究人群中，在患有特发性疾病或明确病因的猫之间没有发现显着的年龄差异。在56.9％的病例中报告了单侧疾病，在特发性病例和确诊病因组中没有差异。最常见的眼科临床症状是房水耀斑，其次是角质沉淀和低张力。虹膜颜色变化（p=0.015）和眼内肿块的存在（p=0.025）与潜在的病因有关。
■特发性葡萄膜炎是本研究人群中最常见的诊断。然而,相似比例的病例具有潜在病因,而在随访时间内表现为系统性疾病的比例较高.仅在四分之一的病例中可以确定潜在的病因。需要进一步的研究来标准化评估患有葡萄膜炎的猫所需的调查，以最大程度地减少患者的发病率。
■为了评估英国非创伤性葡萄膜炎的病因，为了比较特发性病例和具有既定潜在病因的病例之间的诊断特征，并研究临床体征和异常诊断结果与明确病因的关系。
2009年8月至2018年4月在英国转诊中心诊断为葡萄膜炎的猫的记录进行了回顾性回顾。排除创伤性（和反射）病例。根据在确诊病因的病例中是否已确定潜在病因对病例进行分类。特发性,和不确定的案件。除非已经确定了潜在的病因，否则所有病例都至少进行了12个月的随访。人口特征,临床体征,诊断调查功能，并报告了结果。
■包括72例葡萄膜炎，其中雄性猫和家养品种的比例过高。在23.6％的病例中确定了潜在的病因：9.7％患有传染病，5.6%有全身性肿瘤,4.2%有原发性眼肿瘤，4.2%有代谢性疾病。特发性葡萄膜炎占病例的37.5%，其余38.9%没有定论,其中35.7%在随访期内死亡或安乐死。在研究人群中，在患有特发性疾病或明确病因的猫之间没有发现显着的年龄差异。在56.9％的病例中报告了单侧疾病，在特发性病例和确诊病因组中没有差异。最常见的眼科临床症状是房水耀斑，其次是角质沉淀和低张力。虹膜颜色变化（p=0.015）和眼内肿块的存在（p=0.025）与潜在的病因有关。
■特发性葡萄膜炎是本研究人群中最常见的诊断。然而,相似比例的病例具有潜在病因,而在随访时间内表现为系统性疾病的比例较高.仅在四分之一的病例中可以确定潜在的病因。需要进一步的研究来标准化评估患有葡萄膜炎的猫所需的调查，以最大程度地减少患者的发病率。
