PDF(Pubmed)
Abstract：
Bacillus Calmette-Guérin (BCG), is administered intravesically as an adjuvant immunotherapy for the treatment of non-muscle invasive bladder cancer. While mild non-infectious problems can occur in up to 85 % of cases, significant local and systemic complications have been reported in 1-5 % of cases. We report the case of a patient with superficial bladder cancer who developed multiorgan failure after intravesical BCG instillation including the kidney and liver with subsequent haemophagocytic lymphohistiocytosis. Our case illustrates the first reported combination of secondary haemophagocytic lymphohistiocytosis with severe renal and liver failure after BCG immunotherapy for bladder carcinoma. Treatment strategy is discussed.
摘要：
卡介苗(BCG),作为用于治疗非肌肉浸润性膀胱癌的辅助免疫疗法进行膀胱内施用。虽然在85%的病例中可以出现轻度的非感染性问题，在1-5%的病例中报告了显著的局部和全身并发症.我们报告了一例浅表性膀胱癌患者，该患者在膀胱内滴注BCG后出现多器官衰竭，包括肾脏和肝脏，随后出现噬血细胞淋巴组织细胞增多症。我们的病例说明了BCG免疫治疗膀胱癌后，继发性噬血细胞性淋巴组织细胞增多症与严重的肾和肝功能衰竭的首次报道。讨论了治疗策略。
