Abstract：
Artificial implant materials may articulate against native articular cartilage in certain clinical scenarios and the selection of an implant material that results in the least wear on articular cartilage is preferred to maintain normal joint architecture and function. This project compared the wear on porcine femoral condyles induced by articulation against porcine patellae, titanium alloy (Ti6Al4V), ultra high molecular weight polyethylene (UHMWPE), and carbon fibre reinforced polyether-ether-ketone (CFR-PEEK) through an ex vivo experimental setup. A sinusoidal compressive load of 30-160 N, representing an approximate joint pressure of 0.19-1 MPa at a frequency of 3 Hz coupled with a rotational displacement of +/- 10⁰ at 3 Hz was used to simulate physiological joint motion. Wear was characterized via gross examination and histologically using the OARSI scoring system after 43,200 cycles. CFR-PEEK resulted in the most significant wear on articular cartilage compared to titanium alloy and UHMWPE whereas titanium alloy and UHMWPE resulted in similar levels of wear. All materials caused more wear compared to cartilage-on-cartilage testing. The wear mechanism was characterized by progressive loss of proteoglycan content in cartilage in histology samples.
摘要：
在某些临床情况下,人工植入材料可以与天然关节软骨连接,并且优选选择导致关节软骨磨损最小的植入材料以维持正常的关节结构和功能。该项目比较了关节对猪股骨髁的磨损，钛合金(Ti6Al4V),超高分子量聚乙烯(UHMWPE),和碳纤维增强的聚醚醚酮（CFR-PEEK）通过离体实验装置。30-160N的正弦压缩载荷，在3Hz的频率下，关节压力约为0.19-1MPa，并在3Hz下旋转位移为+/-10，用于模拟生理关节运动。在43,200个周期后，通过大体检查和使用OARSI评分系统在组织学上对磨损进行表征。与钛合金和UHMWPE相比，CFR-PEEK对关节软骨的磨损最为明显，而钛合金和UHMWPE的磨损水平相似。与软骨上软骨测试相比，所有材料都会造成更多的磨损。磨损机制的特征在于组织学样品中软骨中蛋白聚糖含量的逐渐损失。
