Abstract：
Bioceramic/polymer composites have dragged a lot of attention for treating hard tissue damage in recent years. In this study, we synthesized barium-doped baghdadite (Ba-BAG), as a novel bioceramic, and later developed fibrous composite poly (hydroxybutyrate) co (hydroxyvalerate)- polycaprolactone (PHBV-PCL) scaffolds containing different amounts of baghdadite (BAG) and Ba-BAG, intended to be used in bone regeneration. Our results demonstrated that BAG and Ba-doped BAG powders were synthesized successfully using the sol-gel method and their microstructural, physicochemical, and cytotoxical properties results were evaluated. In the following, PHBV/PCL composite scaffolds containing different amounts of BAG and Ba-BAG (1, 3, and 5 wt%) were produced by the wet electrospinning method. The porosity of scaffolds decreased from 78% to 72% in Ba-BAG-incorporated PHBV/PCL scaffolds. The compressive strength of the scaffolds was between 4.69 and 9.28 kPa, which was increased to their maximum values in the scaffolds with Ba-BAG. The presence of BAG and Ba-BAG in the polymer scaffolds resulted in increasing bioactivity, and it was introduced as a suitable way to control the degradation rate of scaffolds. The presence of the BAG component was a major reason for higher cell proliferation in reinforced PHBV/PCL polymeric scaffolds, while Ba existence played its influential role in the higher osteogenic activity of cells on Ba-BAG incorporated PHBV/PCL scaffolds. Thus, the incorporation of Ba-BAG bioceramic materials into the structure of polymeric PHBV/PCL scaffolds promoted their various properties, and allow these scaffolds to be used as promising candidates in bone tissue engineering applications.
摘要：
近年来，生物陶瓷/聚合物复合材料在治疗硬组织损伤方面受到了广泛的关注。在这项研究中,我们合成了钡掺杂的Baghdadite（Ba-BAG），作为一种新颖的生物陶瓷，后来开发了纤维复合聚（羟基丁酸酯）共（羟基戊酸酯）-聚己内酯（PHBV-PCL）支架，其中含有不同量的Baghdadite（BAG）和Ba-BAG，用于骨再生。我们的结果表明，使用溶胶-凝胶法成功合成了BAG和Ba掺杂的BAG粉末，物理化学,和细胞毒性结果进行了评估。在下文中，通过湿法静电纺丝法制备了含有不同量的BAG和Ba-BAG(1、3和5重量%)的PHBV/PCL复合支架。在掺入Ba-BAG的PHBV/PCL支架中,支架的孔隙率从78%降低至72%。支架的抗压强度在4.69和9.28kPa之间，在带有Ba-BAG的支架中增加到最大值。聚合物支架中BAG和Ba-BAG的存在导致生物活性增加,并将其作为控制支架降解速率的合适方法。BAG组分的存在是增强PHBV/PCL聚合物支架中更高的细胞增殖的主要原因，而Ba的存在对Ba-BAG掺入PHBV/PCL支架上细胞的成骨活性有影响。因此，Ba-BAG生物陶瓷材料掺入到聚合PHBV/PCL支架的结构中，促进了它们的各种性能，并允许这些支架在骨组织工程应用中用作有希望的候选者。
