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Abstract：
This study investigated the associations between diet and frailty in lung cancer patients and the potential role of the gut microbiota involved. We assessed dietary intake and frailty status in 231 lung cancer patients by 3-day, 24-h dietary recalls and Fried frailty criteria, respectively, and collected 50 fecal samples for next-generation sequencing. A total of 75 (32.5%) patients were frail, which might be related to significantly lower intake of energy, protein, carbohydrate, dietary fiber, niacin, leucine, some minerals, and a poorer dietary quality as indicated by the Chinese Healthy Eating Index (p < 0.05). Among these, carbohydrate (OR = 0.98; 95% CI 0.96-0.99; p = 0.010), calcium (OR = 0.99; 95% CI 0.99-1.00; p = 0.025), and selenium (OR = 1.03; 95% CI 1.00-1.06; p = 0.022) were all significantly associated with frailty. A multivariate logistic regression analysis showed that the mean risk of frailty was 0.94 times lower (95% CI 0.90-0.99; p = 0.009) among participants with higher CHEI scores. Additionally, the frail patients demonstrated significantly lower gut microbiota β diversity (p = 0.001) and higher relative abundance of Actinobacteriota (p = 0.033). Frailty in lung cancer patients might be associated with insufficient nutrients intake and a poor dietary quality through gut microbiota regulation.
摘要：
这项研究调查了肺癌患者饮食与虚弱之间的关联以及所涉及的肠道微生物群的潜在作用。我们在3天之前评估了231名肺癌患者的饮食摄入和虚弱状态，24小时饮食召回和油炸虚弱标准，分别,并收集了50份粪便样本用于下一代测序。共有75例(32.5%)患者身体虚弱,这可能与显著降低的能量摄入有关，蛋白质，碳水化合物，膳食纤维，烟酸,亮氨酸,一些矿物质,中国健康饮食指数(p<0.05)表明膳食质量较差。其中,碳水化合物（OR=0.98；95%CI0.96-0.99；p=0.010），钙（OR=0.99；95%CI0.99-1.00；p=0.025），和硒(OR=1.03;95%CI1.00-1.06;p=0.022)均与虚弱显著相关。多因素logistic回归分析显示，CHEI评分较高的参与者中，虚弱的平均风险降低了0.94倍（95％CI0.90-0.99；p=0.009）。此外,体弱患者表现出显著较低的肠道菌群β多样性(p=0.001)和较高的放线菌相对丰度(p=0.033)。肺癌患者的虚弱可能与营养摄入不足和通过肠道微生物群调节的饮食质量差有关。
