PDF(Pubmed)
Abstract：
BACKGROUND: As the COVID-19 pandemic evolved, concerns grew about its impact on pregnant women. This study aimed to determine how SARS-CoV-2 affects pregnancy, birth, and newborns, in order to identify vulnerable individuals and provide proper care.
METHODS: This is a retrospective case-control study of 398 pregnant women who delivered at the Emergency Clinical County Hospital in Sibiu, Romania from 1 February 2020 to 31 March 2022. Patients were initially grouped and compared based on their RT-PCR SARS-CoV-2 test results into the COVID group (cases) (N = 199) and non-COVID group (control) (N = 199). The COVID cases were further divided and compared according to the pre-Delta (N = 105) and Delta/Omicron (N = 94) SARS-CoV-2 variants. COVID cases and control groups were compared to identify correlations between sociodemographic factors, pregnancy outcomes, and SARS-CoV-2 infection. The same comparisons were performed between pre-Delta and Delta/Omicron groups.
RESULTS: There were no significant differences concerning maternal residence, while educational level and employment proportion were higher among the positively tested patients. No significant differences were found for neonatal and pregnancy complications between COVID cases and control groups. Except for a lower mean gestational age, no significant differences were found between pre-Delta and Delta/Omicron periods. The maternal mortality in the infected group was 0.5% (1 case).
CONCLUSIONS: Our study showed that SARS-CoV-2 infection at birth did not significantly affect maternal and neonatal outcomes, not even considering the SARS-CoV-2 strain.
METHODS: This is a retrospective case-control study of 398 pregnant women who delivered at the Emergency Clinical County Hospital in Sibiu, Romania from 1 February 2020 to 31 March 2022. Patients were initially grouped and compared based on their RT-PCR SARS-CoV-2 test results into the COVID group (cases) (N = 199) and non-COVID group (control) (N = 199). The COVID cases were further divided and compared according to the pre-Delta (N = 105) and Delta/Omicron (N = 94) SARS-CoV-2 variants. COVID cases and control groups were compared to identify correlations between sociodemographic factors, pregnancy outcomes, and SARS-CoV-2 infection. The same comparisons were performed between pre-Delta and Delta/Omicron groups.
RESULTS: There were no significant differences concerning maternal residence, while educational level and employment proportion were higher among the positively tested patients. No significant differences were found for neonatal and pregnancy complications between COVID cases and control groups. Except for a lower mean gestational age, no significant differences were found between pre-Delta and Delta/Omicron periods. The maternal mortality in the infected group was 0.5% (1 case).
CONCLUSIONS: Our study showed that SARS-CoV-2 infection at birth did not significantly affect maternal and neonatal outcomes, not even considering the SARS-CoV-2 strain.
摘要：
背景：随着COVID-19大流行的演变，人们越来越担心它对孕妇的影响。这项研究旨在确定SARS-CoV-2如何影响怀孕，出生,和新生儿，以识别弱势群体并提供适当的护理。
方法：这是一项回顾性病例对照研究，对在锡比乌急诊临床县医院分娩的398名孕妇进行了回顾性病例对照研究，罗马尼亚从2020年2月1日至2022年3月31日。最初根据RT-PCRSARS-CoV-2检测结果将患者分为COVID组（病例）（N=199）和非COVID组（对照）（N=199）。根据前Delta（N=105）和Delta/Omicron（N=94）SARS-CoV-2变体对COVID病例进行了进一步划分和比较。比较COVID病例和对照组，以确定社会人口统计学因素之间的相关性，妊娠结局,和SARS-CoV-2感染。在前Delta组和Delta/Omicron组之间进行相同的比较。
结果：产妇居住地无显著差异，而接受阳性测试的患者中，受教育程度和就业比例较高。COVID病例组新生儿和妊娠并发症与对照组差异无统计学意义。除了较低的平均胎龄，在前Delta和Delta/Omicron时期之间没有发现显着差异。感染组产妇死亡率为0.5%(1例)。
结论：我们的研究表明，出生时SARS-CoV-2感染对母婴结局没有显著影响，甚至不考虑SARS-CoV-2菌株。
方法：这是一项回顾性病例对照研究，对在锡比乌急诊临床县医院分娩的398名孕妇进行了回顾性病例对照研究，罗马尼亚从2020年2月1日至2022年3月31日。最初根据RT-PCRSARS-CoV-2检测结果将患者分为COVID组（病例）（N=199）和非COVID组（对照）（N=199）。根据前Delta（N=105）和Delta/Omicron（N=94）SARS-CoV-2变体对COVID病例进行了进一步划分和比较。比较COVID病例和对照组，以确定社会人口统计学因素之间的相关性，妊娠结局,和SARS-CoV-2感染。在前Delta组和Delta/Omicron组之间进行相同的比较。
结果：产妇居住地无显著差异，而接受阳性测试的患者中，受教育程度和就业比例较高。COVID病例组新生儿和妊娠并发症与对照组差异无统计学意义。除了较低的平均胎龄，在前Delta和Delta/Omicron时期之间没有发现显着差异。感染组产妇死亡率为0.5%(1例)。
结论：我们的研究表明，出生时SARS-CoV-2感染对母婴结局没有显著影响，甚至不考虑SARS-CoV-2菌株。
