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Abstract：
BACKGROUND: Childhood glaucoma is one of the most common causes of corneal opacity in childhood and is associated with various pathological corneal changes, including corneal enlargement, corneal clouding, and edema. Congenital glaucoma (CG) may cause a decrease in vision outcomes due to corneal opacity or clouding, which is often associated with stimulus deprivation amblyopia. Therefore, to create a balance between preventing amblyopia and sustaining corneal clearance, patients with CG can be managed with early penetrating corneal transplantation surgery along with advanced glaucoma management.
OBJECTIVE: To investigate the graft survival rate and factors affecting graft survival in patients with congenital glaucoma who underwent penetrating keratoplasty (PKP).
METHODS: Cross-sectional.
METHODS: Patients with congenital glaucoma who underwent PKP were retrospectively evaluated. The associations between age, corneal diameter, presence of ocular comorbidities, concurrent ocular surgeries with corneal graft, and visual outcomes were assessed.
RESULTS: Among the 30 eyes enrolled in the study, 6 (20%) had aniridia, 6 (20%) had Axenfeld-Rieger syndrome, and 18 (60%) were diagnosed with primary congenital glaucoma. Graft survival rates were 66.6% and 63.33% at 12 and 24 months, respectively. At the end of the follow-up, the overall graft survival rate was 60%. Statistical significance was observed between patient age at the time of surgery and graft failure (p = 0.02). Graft failure was associated with a younger patient age. Functional vision was achieved in 53.3% of patients.
CONCLUSIONS: The management of congenital glaucoma and its corneal complications is a delicate issue that requires great effort. PKP in congenital glaucoma was moderately successful in the present study. To provide functional vision, PKP could be the treatment of choice.
OBJECTIVE: To investigate the graft survival rate and factors affecting graft survival in patients with congenital glaucoma who underwent penetrating keratoplasty (PKP).
METHODS: Cross-sectional.
METHODS: Patients with congenital glaucoma who underwent PKP were retrospectively evaluated. The associations between age, corneal diameter, presence of ocular comorbidities, concurrent ocular surgeries with corneal graft, and visual outcomes were assessed.
RESULTS: Among the 30 eyes enrolled in the study, 6 (20%) had aniridia, 6 (20%) had Axenfeld-Rieger syndrome, and 18 (60%) were diagnosed with primary congenital glaucoma. Graft survival rates were 66.6% and 63.33% at 12 and 24 months, respectively. At the end of the follow-up, the overall graft survival rate was 60%. Statistical significance was observed between patient age at the time of surgery and graft failure (p = 0.02). Graft failure was associated with a younger patient age. Functional vision was achieved in 53.3% of patients.
CONCLUSIONS: The management of congenital glaucoma and its corneal complications is a delicate issue that requires great effort. PKP in congenital glaucoma was moderately successful in the present study. To provide functional vision, PKP could be the treatment of choice.
摘要：
背景：儿童青光眼是儿童角膜混浊的最常见原因之一，并与各种病理性角膜改变有关，包括角膜肿大,角膜混浊,和水肿。先天性青光眼（CG）可能由于角膜混浊或混浊而导致视力下降，这通常与刺激剥夺弱视有关。因此,在预防弱视和维持角膜清除之间建立平衡，CG患者可以通过早期穿透性角膜移植手术以及晚期青光眼治疗来治疗。
目的：探讨先天性青光眼行穿透性角膜移植术(PKP)患者的移植物存活率及影响移植物存活的因素。
方法：横断面。
方法：对接受PKP治疗的先天性青光眼患者进行回顾性评估。年龄之间的关联，角膜直径,眼合并症的存在，同时进行角膜移植的眼部手术，和评估视觉结果。
结果：在参与研究的30只眼中，6人（20%）患有无虹膜，6人（20%）患有Axenfeld-Rieger综合征，18例（60％）被诊断为原发性先天性青光眼。12个月和24个月移植物存活率分别为66.6%和63.33%,分别。在后续行动结束时，移植物总存活率为60%。在手术时的患者年龄与移植物失败之间观察到统计学显著性(p=0.02)。移植失败与患者年龄较小有关。53.3%的患者实现了功能性视力。
结论：先天性青光眼及其角膜并发症的治疗是一个棘手的问题，需要付出巨大的努力。在本研究中，先天性青光眼的PKP进展顺利。为了提供功能视觉，PKP可能是治疗的选择。
目的：探讨先天性青光眼行穿透性角膜移植术(PKP)患者的移植物存活率及影响移植物存活的因素。
方法：横断面。
方法：对接受PKP治疗的先天性青光眼患者进行回顾性评估。年龄之间的关联，角膜直径,眼合并症的存在，同时进行角膜移植的眼部手术，和评估视觉结果。
结果：在参与研究的30只眼中，6人（20%）患有无虹膜，6人（20%）患有Axenfeld-Rieger综合征，18例（60％）被诊断为原发性先天性青光眼。12个月和24个月移植物存活率分别为66.6%和63.33%,分别。在后续行动结束时，移植物总存活率为60%。在手术时的患者年龄与移植物失败之间观察到统计学显著性(p=0.02)。移植失败与患者年龄较小有关。53.3%的患者实现了功能性视力。
结论：先天性青光眼及其角膜并发症的治疗是一个棘手的问题，需要付出巨大的努力。在本研究中，先天性青光眼的PKP进展顺利。为了提供功能视觉，PKP可能是治疗的选择。
