PDF(Pubmed)
Abstract：
Glaucoma secondary to Peters anomaly is an important factor affecting visual prognosis, but there are few reports on the condition. This study aimed to investigate the characteristics of glaucoma associated with Peters anomaly and glaucoma surgery outcomes. This retrospective study included 31 eyes of 20 patients with Peters anomaly. Peters anomaly was classified into three stages: Stage 1, with a posterior corneal defect only; Stage 2, a corneal defect with iridocorneal adhesion; and Stage 3, a corneal defect with lens abnormalities. The associations between glaucoma and anterior segment dysgenesis severity, visual prognosis, and glaucoma surgery outcomes were analyzed. Sixteen eyes of ten patients developed glaucoma. Stage 1 Peters anomaly had no glaucoma, 52% of Stage 2 had glaucoma, and 75% of Stage 3 had glaucoma. Of the 16 eyes with glaucoma, 11 underwent surgery. Eight of these eleven eyes achieved intraocular pressure (IOP) control. Five of the nine eyes that underwent trabeculotomy (TLO) succeeded, and none had corneal staphyloma. Three of the four eyes for which TLO was ineffective had corneal staphyloma (p = 0.0331). Patients with Peters anomaly are more likely to develop glaucoma as anterior segment dysgenesis progresses, and the effect of TLO is limited if corneal staphyloma is present.
摘要：
继发于Peters异常的青光眼是影响视力预后的重要因素,但是关于这种情况的报道很少。这项研究旨在探讨与Peters异常相关的青光眼的特征和青光眼手术结果。这项回顾性研究包括20例Peters异常患者的31只眼。Peters异常分为三个阶段：第1阶段，仅后角膜缺损；第2阶段，具有虹膜角膜粘连的角膜缺损；第3阶段，具有晶状体异常的角膜缺损。青光眼与眼前节发育不全严重程度之间的关联，视觉预后，并对青光眼手术结果进行分析.10例患者的16只眼发展为青光眼。第一阶段Peters异常没有青光眼,2期的52%有青光眼,3期的75%有青光眼。在16只患有青光眼的眼睛中，11人接受了手术。这11只眼睛中有8只实现了眼内压（IOP）控制。接受小梁切开术（TLO）的九只眼睛中有五只成功，也没有角膜葡萄肿.TLO无效的四只眼睛中有三只患有角膜葡萄肿（p=0.0331）。随着眼前节发育不全的进展，患有Peters异常的患者更有可能发展为青光眼，如果存在角膜葡萄肿，TLO的作用有限。
