PDF(Pubmed)
Abstract：
Previous studies have demonstrated that the intestinal abundance of Bacteroides uniformis is significantly higher in healthy controls than that in patients with ulcerative colitis (UC). However, what effect B. uniformis has on the development of UC has not been characterized. Here, we show for the first time that B. uniformis F18-22, an alginate-fermenting bacterium isolated from the healthy human colon, protects against dextran-sulfate-sodium (DSS)-induced UC in mice. Specifically, oral intake of B. uniformis F18-22 alleviated colon contraction, improved intestinal bleeding and attenuated mucosal damage in diseased mice. Additionally, B. uniformis F18-22 improved gut dysbiosis in UC mice by increasing the abundance of anti-inflammatory acetate-producing bacterium Eubacterium siraeum and decreasing the amount of pro-inflammatory pathogenetic bacteria Escherichia-Shigella spp. Moreover, B. uniformis F18-22 was well-tolerated in mice and showed no oral toxicity after repeated daily administration for 28 consecutive days. Taken together, our study illustrates that B. uniformis F18-22 is a safe and novel probiotic bacterium for the treatment of UC from the healthy human colon.
摘要：
先前的研究表明，健康对照组的肠道均匀拟杆菌丰度明显高于溃疡性结肠炎（UC）患者。然而,B.uniformis对UC的发展有什么影响还没有被描述。这里,我们首次展示了一种从健康人结肠中分离出的藻酸盐发酵细菌。保护小鼠免受葡聚糖-硫酸钠（DSS）诱导的UC。具体来说,口服均匀芽孢杆菌F18-22可减轻结肠收缩，改善患病小鼠的肠道出血和减轻粘膜损伤。此外,均匀芽孢杆菌F18-22通过增加产生抗炎乙酸的细菌西耳杆菌的丰度和减少促炎致病性细菌埃希氏菌-志贺氏菌的数量来改善UC小鼠的肠道菌群失调。此外，均匀芽孢杆菌F18-22在小鼠中具有良好的耐受性,并且在连续28天每天重复给药后没有显示出口服毒性。一起来看,我们的研究表明，均匀芽孢杆菌F18-22是一种安全的新型益生菌，可用于治疗健康人结肠的UC。
