PDF(Pubmed)
Abstract：
9.21.3 chromosomal locus predisposes to coronary heart disease (CHD) and type 2 diabetes mellitus (DM2), but their overall pathological mechanism and clinical applicability remain unclear. The review uses publications of the study results of 9.21.3 chromosomal locus in association with CHD and DM2, which are important for changing the focus of clinical practice. The eligibility criteria are full-text articles published in the PubMed database (MEDLINE) up to December 31, 2022. A total of 56 publications were found that met the inclusion criteria. Using the examples of the progressive stages in understanding the role of the chromosomal locus 9p.21.3, scientific ideas were grouped, from a fragmentary study of independent pathological processes to a systematic study of the overall development of CHD and DM2. The presented review can become a source of new scientific hypotheses for further studies, the results of which can determine the general mechanism of the congenital risk of CHD and DM2 and change the focus of clinical practice.
摘要：
9.21.3染色体位点易患冠心病（CHD）和2型糖尿病（DM2），但其整体病理机制和临床适用性尚不清楚。该综述使用了与CHD和DM2相关的9.21.3染色体位点研究结果的出版物，这对于改变临床实践的重点很重要。资格标准是截至2022年12月31日在PubMed数据库（MEDLINE）中发布的全文文章。共发现56份出版物符合纳入标准。使用渐进阶段的例子来理解染色体位点9p.21.3的作用，对科学思想进行了分组，从对独立病理过程的零碎研究到对CHD和DM2的整体发展的系统研究。提出的评论可以成为进一步研究的新科学假设的来源，其结果可以确定CHD和DM2先天性风险的一般机制，并改变临床实践的重点。
