Abstract：
Rheumatoid arthritis (RA) is typified by persistent joint inflammation, which leads to the deterioration of bone and cartilage and a reduction in overall quality of life. The global prevalence of pain as a primary symptom in RA is influenced by the interplay between inflammation and its resolution. The identification of a family of lipid mediators known as specialized pro-resolving mediators (SPM)s has contributed to the progress of our comprehension of inflammatory conditions. SPMs have been observed to trigger the process of inflammation resolution, thereby reinstating the homeostasis of the inflammatory response. Autacoids are synthesized through the stereo-selective transformation of essential fatty acids, resulting in molecules dynamically modulated during inflammation and possessing strong immunoregulatory properties. This review delves into the available evidence that supports the involvement of certain SPM as protective lipids, biomarkers with potential, and therapeutic targets in the context of RA.
摘要：
类风湿性关节炎（RA）以持续的关节炎症为代表，这导致骨和软骨的恶化和整体生活质量的降低。作为RA主要症状的疼痛的全球患病率受到炎症与其消退之间相互作用的影响。被称为专门的促解决介质（SPM）的脂质介质家族的鉴定为我们对炎症状况的理解的进步做出了贡献。已经观察到SPM触发炎症消退的过程，从而恢复炎症反应的稳态。通过必需脂肪酸的立体选择性转化合成自类化合物，导致分子在炎症过程中动态调节并具有很强的免疫调节特性。这篇综述深入研究了支持某些SPM作为保护性脂质参与的现有证据，具有潜力的生物标志物，和RA背景下的治疗靶标。
