PDF(Pubmed)
Abstract：
Although heritability estimates suggest a role for genetic components, environmental risk factors have been described as relevant in the etiology of attention deficit/hyperactivity disorder (ADHD). Several studies have investigated the role of toxicological pollution, i.e., air pollution, heavy metals, POPs, and phthalates. Clear evidence for association of ADHD and environmental factors has not been provided yet. To answer this, we have assessed all available systematic reviews and meta-analyses that focused on the association between pollutant exposure and either ADHD diagnosis or symptoms. More than 1800 studies were screened of which 14 found eligible. We found evidence of a significant role for some pollutants, in particular heavy metals and phthalates, in the increased risk of developing ADHD symptoms. However, at the current stage, data from existing literature also do not allow to weight the role of the different environmental pollutants. We also offer a critical examination of the reviews/meta-analyses and provide indications for future studies in this field. PROSPERO registration: CRD42022341496.
摘要：
虽然遗传力估计表明了遗传成分的作用，环境危险因素已被描述为与注意缺陷/多动障碍(ADHD)的病因相关.一些研究调查了毒理学污染的作用，即，空气污染,重金属,持久性有机污染物,和邻苯二甲酸酯。尚未提供ADHD与环境因素关联的明确证据。为了回答这个问题，我们评估了所有现有的系统综述和荟萃分析,这些综述和荟萃分析集中于污染物暴露与ADHD诊断或症状之间的关联.筛选了1800多项研究，其中14项符合条件。我们发现了一些污染物有重要作用的证据，特别是重金属和邻苯二甲酸盐，在发展ADHD症状的风险增加。然而,在现阶段,现有文献中的数据也不允许对不同环境污染物的作用进行加权。我们还对评论/荟萃分析进行了严格的检查，并为该领域的未来研究提供了指示。PROSPERO注册：CRD42022341496。
