关键词: COVID-19 SARS-CoV-2 mucomycosis rhino-orbital infection

Mesh : Male Humans Aged Mucorales SARS-CoV-2 Coinfection / diagnosis COVID-19 / complications diagnosis Mucormycosis / complications diagnosis drug therapy Diabetes Mellitus Antifungal Agents

来  源:   DOI:10.3855/jidc.17647

Abstract:
Rhino-orbito-cerebral mucormycosis has been reported as a sequela after coronavirus disease in immunocompromised patients with poorly controlled diabetes mellitus. Most cases have been identified in India, with only 19 reported elsewhere.
We herein report the results of clinical, imaging, microbiological, and histopathological studies in an immunocompetent 67-year-old male with rhino-orbital infection by Finegoldia magna and Mucorales molds following severe SARS-CoV-2 disease associated with new-onset decompensated diabetes mellitus.
Microbiological and histological studies confirmed the presence of both Mucorales molds and Finegoldia magna, which was successfully treated with antibiotics and a specific anti-fungal agent (Posaconazole).
Careful multidisciplinary follow-up of patients treated for severe SARS-CoV-2 disease is necessary for the timely diagnosis of complications such as uncontrolled diabetes mellitus and opportunistic infections.
摘要:
背景:据报道,犀牛-流-脑毛霉菌病是控制不佳的糖尿病免疫受损患者的冠状病毒病后遗症。大多数病例是在印度发现的,其他地方只有19人报道。
方法:我们在此报告临床结果,成像,微生物,以及在患有严重的SARS-CoV-2疾病与新发失代偿性糖尿病相关后,由Finegoldiamagna和Mucorales霉菌感染的具有免疫能力的67岁男性的组织病理学研究。
结果:微生物学和组织学研究证实了Mucorales霉菌和Finegoldiamagna的存在,用抗生素和特定的抗真菌剂(泊沙康唑)成功治疗。
结论:对严重SARS-CoV-2病患者进行仔细的多学科随访,对于及时诊断未控制的糖尿病和机会性感染等并发症是必要的。
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