Abstract：
Objective. The present study was directed to assess the correlation between leukocyte and platelet indices and microvascular complications in patients with type 2 diabetes mellitus (T2DM). Methods. A prospective cross-sectional study was conducted between January 2020 and May 2021 at a tertiary healthcare center. Sixty T2DM patients, who fulfilled the inclusion and exclusion criteria, were included into the study and divided into 2 groups: T2DM patients with microvascular complications and T2DM patients without vascular complications. Clinical history was taken and examinations (routine complete blood count) were done to obtain platelet indices, neutrophillymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and lymphocyte-monocyte ratio (LMR) were obtained and tabulated. A correlation was statistically analyzed from the obtained data, p value <0.05 was considered to be statistically significant. Results. From the patients with microvascular complications, 18 cases suffered from retinopathy and nephropathy. Majority of the participants suffered from moderate non-proliferative retinopathy. The creatine median and absolute neutrophil count (ANC) were significantly higher in T2DM patients with microvascular complications (p<0.0001 and p<0.0054, respectively) compared to T2DM patients without vascular complications. No significant correlation was found between platelet indices, NLR, PLR with regard to fasting blood sugar, post prandial blood sugar, HbA1C in T2DM patients. Conclusions. Since no significant correlation was found between the different platelet indices and microvascular complications, it is evident that these markers cannot be used as the predictors of microvascular complications in T2DM patients.
摘要：
Objective.本研究旨在评估2型糖尿病（T2DM）患者白细胞和血小板指标与微血管并发症之间的相关性。方法。一项前瞻性横断面研究于2020年1月至2021年5月在三级医疗保健中心进行。60例T2DM患者，符合纳入和排除标准的人，纳入研究，分为2组：有微血管并发症的T2DM患者和无血管并发症的T2DM患者。采集临床病史并进行常规全血细胞计数检查以获取血小板指标,中性粒细胞比率（NLR），血小板-淋巴细胞比率（PLR），获得淋巴细胞-单核细胞比率（LMR）并制成表格。从获得的数据进行相关性统计分析，P值<0.05被认为是统计学上显著的。结果。从微血管并发症的患者中，18例患有视网膜病变和肾病。大多数参与者患有中度非增生性视网膜病变。有微血管并发症的T2DM患者的肌酸中位数和绝对中性粒细胞计数（ANC）明显高于无血管并发症的T2DM患者（分别为p<0.0001和p<0.0054）。血小板指标间无明显相关性,NLR,PLR关于空腹血糖，餐后血糖,2型糖尿病患者的HbA1C。Conclusions.由于不同的血小板指数与微血管并发症之间没有发现显着相关性，很明显,这些标志物不能作为T2DM患者微血管并发症的预测因子.
