Abstract：
Aquaporins (AQPs) are a family of transmembrane channel proteins that can rapidly transport water molecules. The main subtype expressed in the epidermis and dermis is AQP3. Studies have confirmed that AQPs exert certain physiological functions in the skin, such as the maintenance of normal shape, the regulation of body temperature, moisturization and hydration, anti-aging, damage repair and antigen presentation. The abnormal expression of AQPs in skin cells can lead to a variety of skin diseases. This review summarizes the relevance of AQPs in dermatophysiological and pathophysiological processes, highlighting their potential as new drug targets for the treatment of skin diseases.
摘要：
水通道蛋白（AQP）是跨膜通道蛋白家族，可以快速运输水分子。在表皮和真皮中表达的主要亚型是AQP3。研究证实AQPs在皮肤中发挥一定的生理功能,例如保持正常的形状，体温的调节，保湿和水合，抗衰老,损伤修复和抗原呈递。AQPs在皮肤细胞中的异常表达可招致多种皮肤病。这篇综述总结了AQPs在皮肤和病理生理过程中的相关性。强调它们作为治疗皮肤病的新药靶点的潜力。
