PDF(Pubmed)
Abstract：
UNASSIGNED: Autoimmune connective tissue diseases (AICTD) present with a myriad of clinical manifestations, including cutaneous. These disorders occur because of immune dysregulation that produces autoantibodies targeting connective tissue and internal organs. Screening these autoantibodies not only aids in the diagnosis but also in predicting specific organ involvement and the risk of complications related to the disease.
UNASSIGNED: This study was conducted (a) to study various cutaneous and systemic manifestations of AICTD, (b) to study the antinuclear antibody (ANA) profile and (c) to determine the association between systemic manifestations and antinuclear antibodies.
UNASSIGNED: Thirty cases of autoimmune connective tissue disease were recruited for the study. A physical examination, clinical profile and ANA profile were done.
UNASSIGNED: Nonscarring alopecia (83.3%) was the commonest cutaneous manifestation noted, followed by photosensitivity (73.3%). The most common system affected was musculoskeletal (67%), followed by renal (40%). Anti-dsDNA antibodies were significantly associated with musculoskeletal involvement (85%) with a P value of 0.038 and anti-Sm antibodies with neurological involvement (87%), followed by renal involvement (75%) with a P value of 0.018 and 0.001, respectively. Anti-SCL 70 antibodies were significantly associated with lung involvement (75%), with a P value of 0.009 and the presence of anti-SS-A antibodies with cardiovascular involvement (40%) with a P value of 0.014.
UNASSIGNED: Antinuclear antibodies are diagnostic as well as prognostic biomarkers for AICTD and contribute to precision medicine. These antibodies serve as markers to pursue involvement of organs, which in turn helps the treating physician to choose appropriate preventive measures.
UNASSIGNED: This study was conducted (a) to study various cutaneous and systemic manifestations of AICTD, (b) to study the antinuclear antibody (ANA) profile and (c) to determine the association between systemic manifestations and antinuclear antibodies.
UNASSIGNED: Thirty cases of autoimmune connective tissue disease were recruited for the study. A physical examination, clinical profile and ANA profile were done.
UNASSIGNED: Nonscarring alopecia (83.3%) was the commonest cutaneous manifestation noted, followed by photosensitivity (73.3%). The most common system affected was musculoskeletal (67%), followed by renal (40%). Anti-dsDNA antibodies were significantly associated with musculoskeletal involvement (85%) with a P value of 0.038 and anti-Sm antibodies with neurological involvement (87%), followed by renal involvement (75%) with a P value of 0.018 and 0.001, respectively. Anti-SCL 70 antibodies were significantly associated with lung involvement (75%), with a P value of 0.009 and the presence of anti-SS-A antibodies with cardiovascular involvement (40%) with a P value of 0.014.
UNASSIGNED: Antinuclear antibodies are diagnostic as well as prognostic biomarkers for AICTD and contribute to precision medicine. These antibodies serve as markers to pursue involvement of organs, which in turn helps the treating physician to choose appropriate preventive measures.
摘要：
■自身免疫性结缔组织病（AICTD）表现出无数的临床表现，包括皮肤。这些疾病的发生是由于产生靶向结缔组织和内脏器官的自身抗体的免疫失调。筛选这些自身抗体不仅有助于诊断，而且有助于预测特定的器官受累和与该疾病相关的并发症的风险。
■本研究的目的是（a）研究AICTD的各种皮肤和全身表现，（b）研究抗核抗体（ANA）谱和（c）确定全身表现与抗核抗体之间的关联。
■本研究招募了30例自身免疫性结缔组织病。体检,进行临床和ANA分析.
■非瘢痕性脱发（83.3%）是最常见的皮肤表现，其次是光敏性（73.3%）。最常见的受影响的系统是肌肉骨骼（67％），其次是肾脏（40％）。抗dsDNA抗体与肌肉骨骼受累（85％）显着相关，P值为0.038，抗Sm抗体与神经系统受累（87％），其次是肾脏受累（75％），P值分别为0.018和0.001。抗SCL70抗体与肺部受累显着相关（75％），P值为0.009，存在心血管受累的抗SS-A抗体（40％），P值为0.014。
■抗核抗体是AICTD的诊断和预后生物标志物，有助于精准医学。这些抗体可作为追求器官受累的标志物，这反过来有助于治疗医生选择适当的预防措施。
■本研究的目的是（a）研究AICTD的各种皮肤和全身表现，（b）研究抗核抗体（ANA）谱和（c）确定全身表现与抗核抗体之间的关联。
■本研究招募了30例自身免疫性结缔组织病。体检,进行临床和ANA分析.
■非瘢痕性脱发（83.3%）是最常见的皮肤表现，其次是光敏性（73.3%）。最常见的受影响的系统是肌肉骨骼（67％），其次是肾脏（40％）。抗dsDNA抗体与肌肉骨骼受累（85％）显着相关，P值为0.038，抗Sm抗体与神经系统受累（87％），其次是肾脏受累（75％），P值分别为0.018和0.001。抗SCL70抗体与肺部受累显着相关（75％），P值为0.009，存在心血管受累的抗SS-A抗体（40％），P值为0.014。
■抗核抗体是AICTD的诊断和预后生物标志物，有助于精准医学。这些抗体可作为追求器官受累的标志物，这反过来有助于治疗医生选择适当的预防措施。
