PDF(Pubmed)
Abstract：
To deal with intra-abdominal sepsis, one of the major global causes of death in hospitalized patients, efficient abscess drainage is crucial. Despite decades of advances, traditional catheters have demonstrated poor drainage and absorption properties due to their simple tubular structures and their dense nonporous surface. Herein, inspired by porous sponges and fractal roots, a multifaceted hydrogel catheter with effective drainage, absorptive, and robust properties, is presented. Its unique fractal structures provide extensive internal branching and a high specific surface area for effective drainage, while the hierarchical porous structures provide a wide range of absorption capabilities. Additionally, its distinctive multi-interpenetration network maintains robust and appropriate mechanical properties, even after absorption multiple times of liquid and mechanical disturbance, allowing for intact removal from the abdominal cavity without harm to the animal in vivo. Besides, the loaded antimicrobial peptides are capable of being released in situ to inhibit the potential for infections. In vivo experiments have demonstrated that this hydrogel catheter efficiently removes lethal abscesses and improves survival. It is believed that this innovative and practical catheter will create a future precedent for hydrogel drainage devices for more effective management of intra-abdominal sepsis.
摘要：
为了治疗腹内脓毒症，住院患者死亡的主要全球原因之一，有效的脓肿引流至关重要。尽管几十年的进步，传统的导管由于其简单的管状结构和致密的无孔表面而表现出较差的引流和吸收性能。在这里，灵感来自多孔海绵和分形根，具有有效引流功能的多面水凝胶导管，吸收性，和强大的属性，是presented。其独特的分形结构提供了广泛的内部分支和有效排水的高比表面积，而分层多孔结构提供了广泛的吸收能力。此外,其独特的多渗透网络保持稳健和适当的机械性能，即使在多次吸收液体和机械扰动后，允许完整地从腹腔中取出，而不会在体内对动物造成伤害。此外,负载的抗微生物肽能够原位释放以抑制感染的可能性。体内实验已经证明,该水凝胶导管有效地去除致死性脓肿并提高存活率。相信这种创新和实用的导管将为水凝胶引流装置创造未来的先例，以更有效地管理腹内败血症。
