Abstract：
OBJECTIVE: To investigate the diagnostic value of symptom questionnaires, sign questionnaires, and the combination of 2 questionnaires for laryngopharyngeal reflux disease (LPRD).
METHODS: Prospective, single-centered.
METHODS: Seventy-seven patients who were hospitalized in the Department of Otolaryngology-Head and Neck Surgery from October 2022 to April 2023 were included.
METHODS: Included patients completed the RSS, RSI, RSA, and RFS questionnaires and underwent 24-hour hypopharyngeal-esophageal multichannel intraluminal impedance-pH monitoring (HEMII-pH). The RSS, RSI, RSA, RFS, RSS+RSA, RSS+RFS, RSI+RSA, RSI+RFS, and RSI+RFS diagnostic value were compared using Cohen\'s k test and receiver operating characteristic analysis.
RESULTS: Based on the 24 hours HEMII-pH results, 52 patients had LPRD, and 25 patients did not have LPRD. The Kappa values of RSS, RSI, RSA, RFS, RSS+RSA,2 RSS+RFS, RSI+RSA, and RSI+RFS with the 24 hours HEMII-pH monitoring results were 0.565, 0.442, 0.318, 0.431, 0.517, 0.631, 0.451, and 0.461, respectively. The RSS+RFS questionnaire had the highest AUC of 0.836 (95% confidence interval [CI] 0.762-0.909) and the RSA questionnaire had the lowest AUC (AUC = 0.665, 95% CI 0.560-0.790). The sensitivity of RSS was the highest (98%), the specificities of RSS+RFS and RSI+RFS were the highest (96%), and the specificity of RSS was the lowest (52%). RSS+RFS had a sensitivity of 75%, second only to RSS and RFS (76%).
CONCLUSIONS: Among the 8 methods, the RSS combined with the RFS had the highest concordance with 24 hours HEMII-pH monitoring results and AUC values when screening for LPRD.
METHODS: Prospective, single-centered.
METHODS: Seventy-seven patients who were hospitalized in the Department of Otolaryngology-Head and Neck Surgery from October 2022 to April 2023 were included.
METHODS: Included patients completed the RSS, RSI, RSA, and RFS questionnaires and underwent 24-hour hypopharyngeal-esophageal multichannel intraluminal impedance-pH monitoring (HEMII-pH). The RSS, RSI, RSA, RFS, RSS+RSA, RSS+RFS, RSI+RSA, RSI+RFS, and RSI+RFS diagnostic value were compared using Cohen\'s k test and receiver operating characteristic analysis.
RESULTS: Based on the 24 hours HEMII-pH results, 52 patients had LPRD, and 25 patients did not have LPRD. The Kappa values of RSS, RSI, RSA, RFS, RSS+RSA,2 RSS+RFS, RSI+RSA, and RSI+RFS with the 24 hours HEMII-pH monitoring results were 0.565, 0.442, 0.318, 0.431, 0.517, 0.631, 0.451, and 0.461, respectively. The RSS+RFS questionnaire had the highest AUC of 0.836 (95% confidence interval [CI] 0.762-0.909) and the RSA questionnaire had the lowest AUC (AUC = 0.665, 95% CI 0.560-0.790). The sensitivity of RSS was the highest (98%), the specificities of RSS+RFS and RSI+RFS were the highest (96%), and the specificity of RSS was the lowest (52%). RSS+RFS had a sensitivity of 75%, second only to RSS and RFS (76%).
CONCLUSIONS: Among the 8 methods, the RSS combined with the RFS had the highest concordance with 24 hours HEMII-pH monitoring results and AUC values when screening for LPRD.
摘要：
目的：探讨症状问卷的诊断价值，签署问卷，和2份喉咽反流病（LPRD）问卷的组合。
方法：前瞻性，单中心。
方法：纳入2022年10月至2023年4月在耳鼻咽喉头颈外科住院的77例患者。
方法：包括完成RSS的患者，RSI,RSA,和RFS问卷调查，并进行了24小时下咽食管多通道腔内阻抗-pH监测（HEMII-pH）。RSS,RSI,RSA,RFS,RSS+RSA,RSS+RFS,RSI+RSA,RSI+RFS,使用Cohenk检验和接收器工作特性分析比较RSI+RFS诊断值。
结果：基于24小时HEMII-pH结果，52例患者患有LPRD，25例患者没有LPRD。RSS的Kappa值，RSI,RSA,RFS,RSS+RSA,2RSS+RFS,RSI+RSA,RSI+RFS与24小时HEMII-pH监测结果分别为0.565、0.442、0.318、0.431、0.517、0.631、0.451和0.461。RSS+RFS问卷的AUC最高，为0.836（95%置信区间[CI]0.762-0.909），RSA问卷的AUC最低（AUC=0.665，95%CI0.560-0.790）。RSS的灵敏度最高(98%),RSS+RFS和RSI+RFS的特异性最高(96%)，RSS的特异性最低(52%)。RSS+RFS的灵敏度为75%。仅次于RSS和RFS(76%)。
结论：在8种方法中，在筛查LPRD时,RSS联合RFS与24小时HEMII-pH监测结果和AUC值的一致性最高.
方法：前瞻性，单中心。
方法：纳入2022年10月至2023年4月在耳鼻咽喉头颈外科住院的77例患者。
方法：包括完成RSS的患者，RSI,RSA,和RFS问卷调查，并进行了24小时下咽食管多通道腔内阻抗-pH监测（HEMII-pH）。RSS,RSI,RSA,RFS,RSS+RSA,RSS+RFS,RSI+RSA,RSI+RFS,使用Cohenk检验和接收器工作特性分析比较RSI+RFS诊断值。
结果：基于24小时HEMII-pH结果，52例患者患有LPRD，25例患者没有LPRD。RSS的Kappa值，RSI,RSA,RFS,RSS+RSA,2RSS+RFS,RSI+RSA,RSI+RFS与24小时HEMII-pH监测结果分别为0.565、0.442、0.318、0.431、0.517、0.631、0.451和0.461。RSS+RFS问卷的AUC最高，为0.836（95%置信区间[CI]0.762-0.909），RSA问卷的AUC最低（AUC=0.665，95%CI0.560-0.790）。RSS的灵敏度最高(98%),RSS+RFS和RSI+RFS的特异性最高(96%)，RSS的特异性最低(52%)。RSS+RFS的灵敏度为75%。仅次于RSS和RFS(76%)。
结论：在8种方法中，在筛查LPRD时,RSS联合RFS与24小时HEMII-pH监测结果和AUC值的一致性最高.
