Abstract：
BACKGROUND: The United States currently faces a public health crisis with regarding to antibiotic-resistant bacteria, and new urinary tract infection (UTI) diagnostics are needed. Women with recurrent UTI (rUTI) and complicated UTI (cUTI) are at particular risk given their complexity and the paucity of adequate testing modalities. The standard urine culture (SUC) is the cornerstone for diagnosis, but it has many shortcomings. These pitfalls lead to dissatisfaction and frustration among women afflicted with rUTI and cUTI, as well as overuse of antibiotics. One innovation is PCR UTI testing, which has been shown to outperform SUC among symptomatic women.
OBJECTIVE: This article discusses UTI PCR testing, as well as a possible role in clinical practice.
METHODS: Published literature was reviewed and summarized.
RESULTS: Management of rUTI and cUTI is complex, and providers should have all diagnostics available to facilitate providing optimal care. Urine PCR testing faces reimbursement issues despite fulfilling clinical indication parameters as described by insurance companies.
CONCLUSIONS: The role of UTI PCR testing remains unclear. Reimbursement issues have led to underuse and limited real-world outcomes reinforcing benefit.
CONCLUSIONS: This study proposes an algorithm for PCR testing among women with rUTI and cUTI.
OBJECTIVE: This article discusses UTI PCR testing, as well as a possible role in clinical practice.
METHODS: Published literature was reviewed and summarized.
RESULTS: Management of rUTI and cUTI is complex, and providers should have all diagnostics available to facilitate providing optimal care. Urine PCR testing faces reimbursement issues despite fulfilling clinical indication parameters as described by insurance companies.
CONCLUSIONS: The role of UTI PCR testing remains unclear. Reimbursement issues have led to underuse and limited real-world outcomes reinforcing benefit.
CONCLUSIONS: This study proposes an algorithm for PCR testing among women with rUTI and cUTI.
摘要：
背景：美国目前面临关于抗生素抗性细菌的公共卫生危机，和新的尿路感染（UTI）诊断是必要的。患有复发性UTI（rUTI）和复杂UTI（cUTI）的妇女由于其复杂性和缺乏适当的检测方式而处于特别的风险中。标准尿培养（SUC）是诊断的基石，但是它有很多缺点。这些陷阱导致患有rUTI和cUTI的妇女的不满和沮丧，以及过度使用抗生素。一项创新是PCRUTI测试，在有症状的女性中，这已被证明优于SUC。
目的：本文讨论UTIPCR检测，以及在临床实践中可能的作用。
方法：对已发表的文献进行综述和总结。
结果：rUTI和cUTI的管理很复杂，和提供者应提供所有诊断，以促进提供最佳护理。尽管符合保险公司描述的临床适应症参数，但尿液PCR测试仍面临报销问题。
结论：UTIPCR检测的作用尚不清楚。偿还问题导致使用不足和现实世界结果有限，从而增强了收益。
结论：本研究提出了一种对rUTI和cUTI女性进行PCR检测的算法。
目的：本文讨论UTIPCR检测，以及在临床实践中可能的作用。
方法：对已发表的文献进行综述和总结。
结果：rUTI和cUTI的管理很复杂，和提供者应提供所有诊断，以促进提供最佳护理。尽管符合保险公司描述的临床适应症参数，但尿液PCR测试仍面临报销问题。
结论：UTIPCR检测的作用尚不清楚。偿还问题导致使用不足和现实世界结果有限，从而增强了收益。
结论：本研究提出了一种对rUTI和cUTI女性进行PCR检测的算法。
