PDF(Pubmed)
Abstract：
Cell-fate decisions depend on the precise and strict regulation of multiple signaling molecules and transcription factors, especially intracellular Ca2+ homeostasis and dynamics. Type 3 inositol 1,4,5-triphosphate receptor (IP3R3) is an a tetrameric channel that can mediate the release of Ca2+ from the endoplasmic reticulum (ER) in response to extracellular stimuli. The gating of IP3R3 is regulated not only by ligands but also by other interacting proteins. To date, extensive research conducted on the basic structure of IP3R3, as well as its regulation by ligands and interacting proteins, has provided novel perspectives on its biological functions and pathogenic mechanisms. This review aims to discuss recent advancements in the study of IP3R3 and provides a comprehensive overview of the relevant literature pertaining to its structure, biological functions, and pathogenic mechanisms.
摘要：
细胞命运的决定取决于多种信号分子和转录因子的精确和严格的调控。特别是细胞内Ca2+稳态和动力学。3型肌醇1,4,5-三磷酸受体（IP3R3）是一种四聚体通道，可以介导Ca2从内质网（ER）释放，以响应细胞外刺激。IP3R3的门控不仅受配体的调节，而且受其他相互作用蛋白的调节。迄今为止,对IP3R3的基本结构以及配体和相互作用蛋白的调控进行了广泛的研究，对其生物学功能和致病机制提供了新的观点。这篇综述旨在讨论IP3R3研究的最新进展，并提供有关其结构的相关文献的全面概述，生物学功能,和致病机制。
