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Abstract：
Background Malnutrition in hospitalized patients is a significant problem. This study aimed to assess the utility of the Subjective Global Assessment (SGA) in predicting the association between serum biomarkers and malnutrition in patients with limb injuries as well as the impact of malnutrition on clinical and radiological bone healing. Methodology This prospective study included 93 patients with limb injuries. Basic demographic details, serum biomarker levels, nutritional status assessed using the SGA, and the correlation of the Radiological Union Shaft Tibia (RUST) score with nutrition status were assessed along with the secondary outcomes. Results According to the SGA, patients were classified into Group A (well-nourished), Group B (moderately malnourished), and Group C (severely malnourished). Serum biomarkers (albumin, hemoglobin, platelets, and total leucocyte count) were significantly higher in Group A than in Group B + C (p < 0.0001). The nutritional status of patients from admission up to six months in Group A was significantly higher (p < 0.0001) compared to Group B + C. The radiological healing according to the RUST score had a negative correlation with C-reactive protein and a positive correlation with various parameters at six months. Conclusions The serum biomarker levels and the clinical and radiological bone healing, as measured by the RUST scoring system, showed a positive correlation with the nutritional status of the patients. Malnutrition significantly increases the chance of developing complications such as wound infection, decubitus, and infected implants.
摘要：
背景：住院患者的营养不良是一个严重的问题。这项研究旨在评估主观整体评估（SGA）在预测肢体损伤患者血清生物标志物与营养不良之间的关联以及营养不良对临床和放射学骨愈合的影响方面的实用性。方法这项前瞻性研究包括93例肢体损伤患者。基本的人口统计细节,血清生物标志物水平，使用SGA评估营养状况，评估胫骨放射学联合轴(RUST)评分与营养状况的相关性以及次要结局.结果根据SGA,患者被分为A组（营养良好），B组（中度营养不良），和C组（严重营养不良）。血清生物标志物(白蛋白，血红蛋白,血小板,和总白细胞计数）在A组中明显高于BC组（p<0.0001）。A组患者入院至6个月的营养状况明显高于B+C组（p<0.0001）。根据RUST评分的放射学愈合与C反应蛋白呈负相关，与6个月时的各种参数呈正相关。结论血清生物标志物水平与临床和放射学骨愈合有关,根据RUST评分系统的测量，与患者的营养状况呈正相关。营养不良显著增加了发生伤口感染等并发症的机会,褥疮,和受感染的植入物。
