PDF(Pubmed)
Abstract：
Breast cancer is currently the most common malignancy and has a high mortality rate. Ginsenosides, the primary bioactive constituents of ginseng, have been shown to be highly effective against breast cancer both in vitro and in vivo. This study aims to comprehensively understand the mechanisms underlying the antineoplastic effects of ginsenosides on breast cancer. Through meticulous bibliometric analysis and an exhaustive review of pertinent research, we explore and summarize the mechanism of action of ginsenosides in treating breast cancer, including inducing apoptosis, autophagy, inhibiting epithelial-mesenchymal transition and metastasis, and regulating miRNA and lncRNA. This scholarly endeavor not only provides novel prospects for the application of ginsenosides in the treatment of breast cancer but also suggests future research directions for researchers.
摘要：
乳腺癌是目前最常见的恶性肿瘤，死亡率高。人参皂苷,人参的主要生物活性成分，已被证明在体外和体内对乳腺癌都非常有效。本研究旨在全面了解人参皂苷对乳腺癌的抗肿瘤作用机制。通过细致的文献计量分析和对相关研究的详尽回顾，探讨和总结人参皂苷治疗乳腺癌的作用机制,包括诱导细胞凋亡，自噬,抑制上皮-间质转化和转移，调节miRNA和lncRNA。这一研究成果不仅为人参皂苷在乳腺癌治疗中的应用提供了新的前景，也为研究人员提出了未来的研究方向。
