PDF(Pubmed)
Abstract：
UNASSIGNED: Compared to the general population, the risk of suicide is three times higher in patients with epilepsy and remains doubled for these patients even after adjusting for sociodemographic correlates of suicide in the absence of mental health comorbidities. Following the United States (US) Food and Drug Administration (FDA) alert prompting a black box warning regarding the association between suicidality and antiepileptic drugs (AEDs), several studies were conducted, the results of which have been ambiguous, with some demonstrating a positive association between suicidality and AEDs, while others did not. This systematic review of literature sought to study the relationship between suicidality and AEDs when used exclusively for treatment of epilepsy.
UNASSIGNED: A comprehensive literature search was conducted on PubMed without time limits using a predefined search language. The search results were then subjected to a systematic screening process. Eight out of a total of 443 articles satisfying predefined inclusion and exclusion criteria were included in the review for final data extraction.
UNASSIGNED: Three studies found a significant association between suicide-related behavior and levetiracetam use in the treatment of epilepsy. One study reported a positive association of pregabalin use in patients with epilepsy under 40 years of age and high AED load with suicidality, independent of depression. The remaining four studies reported a significant association between positive family and personal history of psychiatric comorbidities and suicidality in epilepsy.
UNASSIGNED: Although there were several methodological limitations, this review found an association between levetiracetam use and mental health comorbidities and the occurrence of suicidality in epilepsy. Larger prospective, randomized studies that overcome the limitations of current studies are required to provide definitive evidence on the occurrence of suicidality in patients with epilepsy and AED use.
UNASSIGNED: A comprehensive literature search was conducted on PubMed without time limits using a predefined search language. The search results were then subjected to a systematic screening process. Eight out of a total of 443 articles satisfying predefined inclusion and exclusion criteria were included in the review for final data extraction.
UNASSIGNED: Three studies found a significant association between suicide-related behavior and levetiracetam use in the treatment of epilepsy. One study reported a positive association of pregabalin use in patients with epilepsy under 40 years of age and high AED load with suicidality, independent of depression. The remaining four studies reported a significant association between positive family and personal history of psychiatric comorbidities and suicidality in epilepsy.
UNASSIGNED: Although there were several methodological limitations, this review found an association between levetiracetam use and mental health comorbidities and the occurrence of suicidality in epilepsy. Larger prospective, randomized studies that overcome the limitations of current studies are required to provide definitive evidence on the occurrence of suicidality in patients with epilepsy and AED use.
摘要：
■与普通人群相比，癫痫患者的自杀风险是癫痫患者的三倍,即使在没有精神健康合并症的情况下对自杀的社会人口统计学相关因素进行了调整,这些患者的自杀风险仍然增加了一倍.在美国（US）食品和药物管理局（FDA）警告提示关于自杀和抗癫痫药物（AED）之间的关联的黑匣子警告之后，进行了几项研究，其结果是模棱两可的，一些人证明自杀和AED之间存在正相关，而其他人没有。这篇系统的文献综述旨在研究仅用于治疗癫痫时自杀与AED之间的关系。
■使用预定义的搜索语言在PubMed上进行了无时间限制的全面文献检索。然后对搜索结果进行系统的筛选过程。在总共443篇满足预定义的纳入和排除标准的文章中，有8篇被纳入最终数据提取的审查中。
■三项研究发现，与自杀相关的行为和使用左乙拉西坦治疗癫痫之间存在显著关联。一项研究报道，普瑞巴林的使用与40岁以下癫痫患者和高AED负荷与自杀倾向呈正相关。独立于抑郁症。其余四项研究报告了精神病合并症的阳性家族史和个人病史与癫痫自杀之间的显着关联。
■尽管存在一些方法上的限制，这篇综述发现左乙拉西坦的使用与精神健康合并症和癫痫自杀发生之间存在关联.更大的前景，需要克服现有研究局限性的随机研究,以提供关于癫痫和使用AED患者自杀发生的明确证据.
■使用预定义的搜索语言在PubMed上进行了无时间限制的全面文献检索。然后对搜索结果进行系统的筛选过程。在总共443篇满足预定义的纳入和排除标准的文章中，有8篇被纳入最终数据提取的审查中。
■三项研究发现，与自杀相关的行为和使用左乙拉西坦治疗癫痫之间存在显著关联。一项研究报道，普瑞巴林的使用与40岁以下癫痫患者和高AED负荷与自杀倾向呈正相关。独立于抑郁症。其余四项研究报告了精神病合并症的阳性家族史和个人病史与癫痫自杀之间的显着关联。
■尽管存在一些方法上的限制，这篇综述发现左乙拉西坦的使用与精神健康合并症和癫痫自杀发生之间存在关联.更大的前景，需要克服现有研究局限性的随机研究,以提供关于癫痫和使用AED患者自杀发生的明确证据.
