Abstract：
Depot medroxyprogesterone acetate causes a hypo-estrogenic state in over half of users although clinical vaginal atrophy causing superficial dyspareunia is thought rarely to occur. This is a case series of ten women using depot medroxyprogesterone acetate who presented with superficial dyspareunia and clinical vaginal atrophy. The women were treated with vaginal estriol cream and their contraception was discontinued or changed. All patients had either a complete resolution of symptoms or a substantial improvement at follow-up, and the clinical and laboratory findings of vaginal atrophy had resolved. This case series demonstrates that vaginal atrophy may occur more frequently than previously thought.
摘要：
尽管认为很少发生导致浅表性性交困难的临床阴道萎缩，但醋酸甲羟孕酮在超过一半的使用者中会导致低雌激素状态。这是一个由10名使用醋酸甲羟孕酮的患者组成的病例系列，这些患者表现为浅表性性交困难和临床阴道萎缩。这些妇女接受阴道雌三醇乳膏治疗，并停止或改变她们的避孕方法。所有患者在随访时症状完全缓解或有实质性改善，阴道萎缩的临床和实验室发现已经解决。本病例系列显示，阴道萎缩可能比以前认为的更频繁发生。
