PDF(Pubmed)
Abstract：
This review presents an overview of one of the effective strategies for improving the anticancer impact of many drugs including sorafenib using a drug delivery system by employing nanoparticles that is produced through a biological system. The biological process has a lot of benefits, including being inexpensive and safe for the environment. Sorafenib is one of a multi-kinase inhibitor that inhibits molecularly targeted kinases. Because of its poor pharmacokinetic characteristics, such as fast elimination and limited water solubility, the bioavailability of Sorafenib is extremely low. More intelligent nano formulations of sorafenib have been developed to boost both the drug\'s target ability and bioavailability. Researchers in a wide variety of sectors, including nanomedicine, have recently been interested in the topic of nanotechnology. It is possible for the body to develop resistance to widely used drugs available for treatment of liver cancer, including sorafenib. As a result, our goal of this research is to highlight the efficacy of nanomedicine-based drug delivery system to enhance drug\'s cancer-fighting properties. Because of their magnetic properties, certain nanoparticle materials can be employed as a carrier for the medicine to the exact place where the cancer is located. This can lower the amount of the drug that is administered with no impact on the normal cells.
摘要：
这篇综述概述了通过使用生物系统产生的纳米颗粒来改善包括索拉非尼在内的许多药物的抗癌影响的有效策略之一。生物过程有很多好处，包括廉价和安全的环境。索拉非尼是抑制分子靶向激酶的多激酶抑制剂之一。由于其不良的药代动力学特征，如快速消除和有限的水溶性，索拉非尼的生物利用度非常低。已开发出更智能的索拉非尼纳米制剂，以提高药物的靶向能力和生物利用度。各行各业的研究人员，包括纳米医学，最近对纳米技术的话题很感兴趣。身体有可能对可用于治疗肝癌的广泛使用的药物产生耐药性，包括索拉非尼.因此,我们这项研究的目标是强调纳米药物给药系统的功效，以增强药物的抗癌特性。由于它们的磁性，某些纳米颗粒材料可以用作药物的载体，到达癌症所在的确切位置。这可以降低所施用的药物的量而不影响正常细胞。
