PDF(Pubmed)
Abstract：
The rising prevalence of myopia is a concern in ophthalmology, with myopic choroidal neovascularisation (m-CNV) significantly affecting vision. However, long-term outcomes of m-CNV management have been unsatisfactory, leading to high recurrence rates. These studies aim to identify risk factors for m-CNV recurrence.
Comprehensive review followed a pre-registered plan in the International Prospective Register of Systematic Reviews (PROSPERO). The search strategy used various databases including PubMed, Cochrane Library, Embase, Scopus and ScienceDirect using the keywords \'Myopic Choroidal Neovascularization\', \'Recurrence\' and \'Risk\'. Eligible studies were identified and analysed based on predetermined criteria. This study was registered on PROSPERO (CRD4202343461).
The systematic review included three retrospective studies investigating risk factors associated with m-CNV recurrence. These factors are: (1) requiring three or more injections for initial disease control, (2) older age, (3) larger myopic macular neovascularisation, (4) juxtafoveal CNV, (5) larger height of hyper-reflective foci (HRF) and (6) destruction or absence of the ellipsoid zone (EZ) and retinal pigment epithelium (RPE).
Risk factors for m-CNV recurrence include a greater number of required injections, older age, large macular CNV, juxtafoveal location, increased HRF height and changes in EZ and RPE structure. Understanding these factors can inform personalised treatment approaches and improve patient outcomes by identifying individuals at higher risk of recurrence and implementing proactive measures to mitigate the impact of m-CNV recurrence and progression. Further investigation is needed to enhance our understanding of the underlying mechanisms and develop innovative therapeutic approaches for effective m-CNV management.
CRD4202343461.
Comprehensive review followed a pre-registered plan in the International Prospective Register of Systematic Reviews (PROSPERO). The search strategy used various databases including PubMed, Cochrane Library, Embase, Scopus and ScienceDirect using the keywords \'Myopic Choroidal Neovascularization\', \'Recurrence\' and \'Risk\'. Eligible studies were identified and analysed based on predetermined criteria. This study was registered on PROSPERO (CRD4202343461).
The systematic review included three retrospective studies investigating risk factors associated with m-CNV recurrence. These factors are: (1) requiring three or more injections for initial disease control, (2) older age, (3) larger myopic macular neovascularisation, (4) juxtafoveal CNV, (5) larger height of hyper-reflective foci (HRF) and (6) destruction or absence of the ellipsoid zone (EZ) and retinal pigment epithelium (RPE).
Risk factors for m-CNV recurrence include a greater number of required injections, older age, large macular CNV, juxtafoveal location, increased HRF height and changes in EZ and RPE structure. Understanding these factors can inform personalised treatment approaches and improve patient outcomes by identifying individuals at higher risk of recurrence and implementing proactive measures to mitigate the impact of m-CNV recurrence and progression. Further investigation is needed to enhance our understanding of the underlying mechanisms and develop innovative therapeutic approaches for effective m-CNV management.
CRD4202343461.
摘要：
背景：近视患病率上升是眼科关注的问题，近视脉络膜新生血管（m-CNV）显着影响视力。然而,m-CNV管理的长期结果一直不令人满意，导致高复发率。这些研究旨在确定m-CNV复发的危险因素。
方法：综合审查遵循国际前瞻性系统审查登记册（PROSPERO）中预先注册的计划。搜索策略使用了各种数据库，包括PubMed，科克伦图书馆,Embase,Scopus和ScienceDirect使用关键词“近视脉络膜新生血管”，\'重复\'和\'风险\'。根据预定标准鉴定和分析合格的研究。本研究在PROSPERO（CRD4202343461）上注册。
结果：系统评价包括三项回顾性研究，调查与m-CNV复发相关的危险因素。这些因素是：（1）最初的疾病控制需要三次或更多次注射，（2）年龄较大，（3）较大的近视黄斑新生血管，(4)近凹CNV，（5）高反射灶（HRF）的高度较大；（6）椭圆形区（EZ）和视网膜色素上皮（RPE）的破坏或缺失。
结论：m-CNV复发的危险因素包括需要大量的注射，年龄较大,大黄斑CNV,并腹位置，HRF高度增加，EZ和RPE结构发生变化。了解这些因素可以为个性化治疗方法提供信息，并通过识别复发风险较高的个体并实施积极措施以减轻m-CNV复发和进展的影响来改善患者预后。需要进行进一步的研究，以增强我们对潜在机制的理解，并开发创新的治疗方法来进行有效的m-CNV管理。
■CRD4202343461。
方法：综合审查遵循国际前瞻性系统审查登记册（PROSPERO）中预先注册的计划。搜索策略使用了各种数据库，包括PubMed，科克伦图书馆,Embase,Scopus和ScienceDirect使用关键词“近视脉络膜新生血管”，\'重复\'和\'风险\'。根据预定标准鉴定和分析合格的研究。本研究在PROSPERO（CRD4202343461）上注册。
结果：系统评价包括三项回顾性研究，调查与m-CNV复发相关的危险因素。这些因素是：（1）最初的疾病控制需要三次或更多次注射，（2）年龄较大，（3）较大的近视黄斑新生血管，(4)近凹CNV，（5）高反射灶（HRF）的高度较大；（6）椭圆形区（EZ）和视网膜色素上皮（RPE）的破坏或缺失。
结论：m-CNV复发的危险因素包括需要大量的注射，年龄较大,大黄斑CNV,并腹位置，HRF高度增加，EZ和RPE结构发生变化。了解这些因素可以为个性化治疗方法提供信息，并通过识别复发风险较高的个体并实施积极措施以减轻m-CNV复发和进展的影响来改善患者预后。需要进行进一步的研究，以增强我们对潜在机制的理解，并开发创新的治疗方法来进行有效的m-CNV管理。
■CRD4202343461。
