PDF(Pubmed)
Abstract：
Recently, the remarkable success of chimeric antigen receptor T cell (CAR-T) therapy in treating certain tumors has led to numerous studies exploring its potential application to treat non-oncology diseases. This review discusses the progress and evolution of CAR-T cell therapies for treating non-oncology diseases over the past 5 years. Additionally, we summarize the advantages and disadvantages of CAR-T cell therapy in treating non-oncological diseases and identify any difficulties that should be overcome. After conducting an in-depth analysis of the most recent studies on CAR-T technology, we discuss the key elements of CAR-T therapy, such as developing an effective CAR design for non-oncological diseases, controlling the rate and duration of response, and implementing safety measures to reduce toxicity. These studies provide new insights into different delivery strategies, the discovery of new target molecules, and improvements in the safety of CAR-T therapy for non-oncological diseases.
摘要：
最近,嵌合抗原受体T细胞(CAR-T)疗法在治疗某些肿瘤方面取得了显著的成功,导致许多研究探索了其在治疗非肿瘤疾病中的潜在应用.本文综述了近5年来CAR-T细胞治疗非肿瘤疾病的研究进展。此外,我们总结了CAR-T细胞疗法在治疗非肿瘤疾病方面的优势和劣势，并确定了应克服的任何困难。在对CAR-T技术的最新研究进行深入分析后，我们讨论了CAR-T疗法的关键要素，例如为非肿瘤疾病开发有效的CAR设计，控制反应的速率和持续时间，并实施安全措施以减少毒性。这些研究为不同的交付策略提供了新的见解，新目标分子的发现，以及改善CAR-T治疗非肿瘤疾病的安全性。
